Prediction of mammalian virus cross-species transmission based on host proteins

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成果类型：

期刊论文

作者：

Zhang, Zheng*;Lu, Congyu;Mo, Bocheng;Bai, Kehan;Ge, Xing-Yi;...

通讯作者：

Zhang, Zheng;Peng, YS;Zhang, Z

作者机构：

[Peng, Yousong; Zhang, Zheng; Lu, Congyu; Ge, Xing-Yi; Zhang, Z] Hunan Univ, Coll Biol, Bioinformat Ctr, Hunan Prov Key Lab Med Virol, Changsha 410082, Hunan, Peoples R China.

[Zhang, Zheng; Mo, Bocheng; Zhang, Z] Hunan Agr Univ, Coll Plant Protect, Hunan Engn & Technol Res Ctr Agr Big Data Anal & D, Changsha, Hunan, Peoples R China.

[Bai, Kehan] Hunan Juyoubiotech Co Ltd, Changsha, Hunan, Peoples R China.

[Deng, Li] Third Hosp Changsha, Dept Internal Med Neurol, Changsha, Hunan, Peoples R China.

通讯机构：

[Peng, YS ; Zhang, Z ; Zhang, Z] H

Hunan Univ, Coll Biol, Bioinformat Ctr, Hunan Prov Key Lab Med Virol, Changsha 410082, Hunan, Peoples R China.

Hunan Agr Univ, Coll Plant Protect, Hunan Engn & Technol Res Ctr Agr Big Data Anal & D, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

mammalian virus;virus cross-species transmission;bioinformatics;zoonotic viruses

期刊：

MICROBIOLOGY SPECTRUM

ISSN：

2165-0497

年：

2023

卷：

期：

页码：

e0536822

DOI：

10.1128/spectrum.05368-22

基金类别：

MOST \ National Natural Science Foundation of China (NSFC) [32170651]; HSTD \ Natural Science Foundation of Hunan Province [2020JJ3006, 2023JJ40323]; Xiaohe Sci-Tech Talents Special Funding under Hunan Provincial Sci-Tech Talents Sponsorship Program [2023TJ-X73]; Scientific Research program of the Educational Department of Hunan Province [22C0097]; Double-First Class Construction Funds of Hunan University [521119400156]

机构署名：

本校为通讯机构

院系归属：

植物保护学院

摘要：

Most emerging viruses are spilled over from mammals. Understanding the mechanism of virus cross-species transmission and identifying zoonotic viruses before their emergence are critical for the prevention and control of newly emerging viruses. This study systematically investigated the host proteins associated with the cross-species transmission of mammalian viruses based on 1,271 pairs of virus-mammal interactions including 382 viruses from 33 viral families and 73 mammal species from 11 orders. Numerous host proteins were found to contribute to the cross-species transmission of mammalian vir...

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Prediction of mammalian virus cross-species transmission based on host proteins

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