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Nontoxic dose of Phenethyl isothiocyanate ameliorates deoxynivalenol-induced cytotoxicity and inflammation in IPEC-J2 cells

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成果类型:
期刊论文
作者:
Liu, Shuiping;Lin, Ziman;Mao, Xinru;Ge, Lei;Hou, Lili;...
通讯作者:
Huang, Kehe
作者机构:
[Le, Guannan; Ge, Lei; Liu, Shuiping; Lin, Ziman; Huang, Kehe; Hou, Lili; Mao, Xinru; Gan, Fang] Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China.
[Le, Guannan; Ge, Lei; Liu, Shuiping; Lin, Ziman; Huang, Kehe; Hou, Lili; Mao, Xinru; Gan, Fang] Nanjing Agr Univ, Inst Nutr & Metab Disorders Domest Anim & Fowls, Nanjing 210095, Jiangsu, Peoples R China.
[Le, Guannan; Ge, Lei; Liu, Shuiping; Lin, Ziman; Huang, Kehe; Hou, Lili; Mao, Xinru; Gan, Fang] Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing 210095, Jiangsu, Peoples R China.
[Wen, Lixin] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.
通讯机构:
[Kehe Huang] C
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China<&wdkj&>Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China<&wdkj&>MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China
语种:
英文
关键词:
Deoxynivalenol;IPEC-J2 cell;Inflammation;NF-κB signal pathway;Phenethyl isothiocyanate
期刊:
Research in Veterinary Science
ISSN:
0034-5288
年:
2021
卷:
136
页码:
66-73
基金类别:
Acknowledgements This project was supported by the funding from the National Natural Science Foundation of China (31772811 and 31602123) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (Jiangsu, China). We would like to extend our gratitude to the platform provided by College of Veterinary Medicine, Nanjing Agricultural University.
机构署名:
本校为其他机构
院系归属:
动物医学院
摘要:
The intestinal tract is a target for the deoxynivalenol (DON), which has adverse effects in animals and humans' health by affecting intestinal functions. Phenethyl isothiocyanate (PEITC) is an important degradation product of glucosinolates (GSLs), belonging to an anti-nutritional factor that affects the digestion and absorption of nutrients in the animals' intestinal. However, little attention has been paid to the interaction and its mechanism between DON and PEITC. Therefore, the purpose of this study was to assess the effects of PEITC on DON-induced cytotoxicity and inflammation, and explor...

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