Blockade of the Formation of Insoluble Ubiquitinated Protein Aggregates by EGCG3 \'\' Me in the Alloxan-Induced Diabetic Kidney - 成果

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Blockade of the Formation of Insoluble Ubiquitinated Protein Aggregates by EGCG3 '' Me in the Alloxan-Induced Diabetic Kidney

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成果类型：

期刊论文

作者：

Cai, Shuxian;Zhong, Yuan;Li, Yinhua;Huang, Jianan;Zhang, Jing;...

通讯作者：

Liu, Zhonghua

作者机构：

[Liu, Zhonghua; Zhong, Yuan; Huang, Jianan; Cai, Shuxian] Hunan Agr Univ, Key Lab, Minist Educ Tea Sci, Changsha, Hunan, Peoples R China.

[Cai, Shuxian] Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing 100871, Peoples R China.

[Zhang, Jing; Li, Yinhua; Liu, Zhonghua; Zhong, Yuan] Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Changsha, Hunan, Peoples R China.

[Liu, Zhonghua; Luo, Guoan] Tsinghua Univ, Dept Chem Tsinghua, Beijing 100084, Peoples R China.

[Liu, Zhonghua; Luo, Guoan] Tsinghua Univ, Key Lab Biol Organ Phosphorus & Chem Biol, Minist Educ, Beijing 100084, Peoples R China.

通讯机构：

[Liu, Zhonghua] H

Hunan Agr Univ, Key Lab, Minist Educ Tea Sci, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Diabetes mellitus;Kidneys;Amides;Protein structure;Serum proteins;Blood sugar;Mouse models;Lipids

期刊：

PLOS ONE

ISSN：

1932-6203

年：

2013

卷：

期：

页码：

e75687

DOI：

10.1371/journal.pone.0075687

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31100501]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2012M520128]; National Science and Technology Support Program [2011BAD01B01]; Ministry of Education Innovation Team Program [201042]; National Tea Industry Technology System Projects [CARS-23-C]

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

摘要：

Background: Renal accumulation of reactive carbonyl compounds (RCCs) has been linked to the progression of diabetic nephropathy. We previously demonstrated that carbonyl stress induces the formation of amino-carbonyl cross-links and sharply increases the content of beta-sheet-rich structures, which is the seed of insoluble aggregates formation, and tea catechin (-)-epigallocatechin 3-gallate (EGCG) can reverse this process in vitro and in vivo. In this study, methylated derivative (-)-epigallocatechin-3-O-(3-O-methyl)-gallate (EGCG3 '' Me) was hypothesized to neutralize carbonyl stress mediati...

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Blockade of the Formation of Insoluble Ubiquitinated Protein Aggregates by EGCG3 '' Me in the Alloxan-Induced Diabetic Kidney

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