Theaflavins mitigate diabetic symptoms in GK rats by modulating the INSR/PI3K-Akt/GSK-3 pathway and intestinal microbiota

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成果类型：

期刊论文

作者：

Liu, Changwei;Zeng, Hongzhe;Cui, Wenyu;Ouyang, Jian;Zhou, Fang;...

通讯作者：

Zhang, Sheng;Huang, Jianan;Liu, ZH

作者机构：

[Huang, Jianan; Liu, Changwei; Zhang, Sheng; Liu, Zhonghua; Fang, Wenwen; Zhou, Fang; Wen, Shuai; Zeng, Hongzhe; Ouyang, Jian] Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Hunan, Peoples R China.

[Liu, Changwei] Hunan Univ Sci & Technol, Sch Life & Hlth Sci, Xiangtan 411201, Peoples R China.

[Huang, Jianan; Zhang, Sheng; Liu, Zhonghua] Hunan Agr Univ, Natl Res Ctr Engn & Technol Utilizat Bot Funct Ing, Changsha 410128, Hunan, Peoples R China.

[Huang, Jianan; Zhang, Sheng; Liu, Zhonghua] Hunan Agr Univ, Coinnovat Ctr, Educ Minist Utilizat Bot Funct Ingredients, Changsha 410128, Hunan, Peoples R China.

[Cui, Wenyu] Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China.

通讯机构：

[Huang, JA; Zhang, S; Liu, ZH ] H

Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Natl Res Ctr Engn & Technol Utilizat Bot Funct Ing, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Coinnovat Ctr, Educ Minist Utilizat Bot Funct Ingredients, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Diabetes mellitus;Hypoglycemic;INSR/PI3K-Akt/GSK-3;Intestinal flora;Theaflavins

期刊：

International Journal of Biological Macromolecules

ISSN：

0141-8130

年：

2024

卷：

277

期：

Pt 2

页码：

134331

DOI：

10.1016/j.ijbiomac.2024.134331

基金类别：

National Key Research and Development Program [2022YFE0111200]; Research on the efficient utilization of Yunnan's special tea tree resources [2022xczx-348, 15]; Agriculture Research System of China of MOF; MARA [CARS-19]

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

食品科学技术学院

摘要：

Dietary management and interventions are crucial in the clinical management of diabetes. Numerous active dietary components in black tea have demonstrated positive effects on blood glucose levels and metabolic functions. However, limited research has explored the potential of theaflavins (TF), polyphenols in black tea, for diabetes management. In this study, high-purity TF was administered to Goto-Kakizaki (GK) diabetic model rats for four weeks to investigate its impact on diabetic pathology and analyze the underlying mechanisms through liver transcriptomics, hepatocyte metabolomics, and gut ...

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Theaflavins mitigate diabetic symptoms in GK rats by modulating the INSR/PI3K-Akt/GSK-3 pathway and intestinal microbiota

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