PPARγ mediates the anti-pulmonary fibrosis effect of icaritin

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成果类型：

期刊论文

作者：

Hua, Qingzhong;Huang, Xiaoting;Xie, Weixi;Zhao, Feiyan;Cheng, Haipeng;...

通讯作者：

Can Gu<&wdkj&>Wei Liu<&wdkj&>Siyuan Tang

作者机构：

[Huang, Xiaoting; Liu, Wei; Xie, Weixi; Zhang, Jialu; Hua, Qingzhong; Zeng, Qian; Zhou, Tingting; Gu, Can; Lin, Miao; Wang, Zun; Tang, Siyuan] Cent South Univ, Xiangya Nursing Sch, Changsha, Hunan, Peoples R China.

[Zhao, Feiyan] Hunan Agr Univ, Coll Vet Med, Changsha, Hunan, Peoples R China.

[Cheng, Haipeng; Han, Jianzhong; Luo, Ziqiang] Cent South Univ, Xiangya Sch Med, Dept Physiol, Changsha, Hunan, Peoples R China.

通讯机构：

[Can Gu; Wei Liu; Siyuan Tang] X

Xiangya Nursing School, Central South University, Changsha, Hunan, China

语种：

英文

关键词：

Bleomycin;Icaritin;Myofibroblast;Peroxisome proliferator-activated receptor gamma;Pulmonary fibrosis

期刊：

Toxicology Letters

ISSN：

0378-4274

年：

2021

卷：

350

页码：

81-90

DOI：

10.1016/j.toxlet.2021.06.014

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500056, 81370974]; Hunan Province Natural Science Foundation, China [2016JJ3182, 2020JJ4773]; Fund for the Key Laboratory of Hunan Province,China [2017TP1004]; Innovation-Driven Project of Central South University, China [2018zzts886]

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

BACKGROUND: Pulmonary fibrosis is a fatal lung disease with limited treatment options. Icaritin is the active ingredient derived from the traditional Chinese medical plant Epimedium and possesses many biomedical activities. This study aimed to investigate the effects and molecular mechanisms of icaritin on bleomycin-induced pulmonary fibrosis in mice. METHODS: To assess its preventative effects, bleomycin treated mice received 0, 0.04, 0.2, and 1 mg/kg of icaritin from day 1 onwards. To assess its therapeutic effects, bleomycin treated mice rec...

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PPARγ mediates the anti-pulmonary fibrosis effect of icaritin

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