Dual gatekeepers-modified mesoporous organic silica nanoparticles for synergistic photothermal-chemotherapy of breast cancer

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Wei;Zhong, Fengmin;Wang, Dun;Zhao, Yuqi;Peng, Dongdong;...

通讯作者：

Tang, Shengsong;Yu, Cui-Yun;Wei, H;Tang, SS

作者机构：

[Wei, Hua; Zhao, Yuqi; Yu, Cui-Yun; Wang, Wei; Tang, Shengsong; Li, Shuang; Zhong, Fengmin; Tang, SS; Peng, Dongdong; Wei, H] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharmaceut Sci, Hengyang 421001, Peoples R China.

[Tang, Shengsong; Ning, Qian] Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellige, Huaihua 418000, Peoples R China.

[Tang, Shengsong; Ning, Qian] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410000, Peoples R China.

[Tang, Shengsong; Tang, SS] Hunan Prov Key Lab Antibody Based Drug & Intellige, Huaihua 418000, Peoples R China.

通讯机构：

[Yu, CY; Wei, H ; Tang, SS] U

[Tang, SS ] H

Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharmaceut Sci, Hengyang 421001, Peoples R China.

Hunan Prov Key Lab Antibody Based Drug & Intellige, Huaihua 418000, Peoples R China.

语种：

英文

关键词：

Chemotherapy;Drug delivery;Dual gatekeepers;Mesoporous organic silica nanoparticles (MONs);Photothermal therapy (PTT)

期刊：

Journal of Colloid and Interface Science

ISSN：

0021-9797

年：

2023

卷：

646

页码：

118-128

DOI：

10.1016/j.jcis.2023.05.018

基金类别：

CRediT authorship contribution statement Wei Wang: Investigation, Methodology, Data curation, Writing – original draft. Fengmin Zhong: Investigation, Formal analysis, Data curation, Methodology, Conceptualization. Dun Wang: Methodology. Yuqi Zhao: Methodology. Dongdong Peng: Methodology. Shuang Li: Methodology. Qian Ning: Methodology. Shengsong Tang: acquisition, Project administration, Conceptualization, Writing – review & editing. Cui-Yun Yu: acquisition, Project administration, Conceptualization, Writing – review &

机构署名：

本校为其他机构

院系归属：

生物科学技术学院

摘要：

HYPOTHESIS: Construction of dual gatekeepers-functionalized mesoporous organic silica nanoparticles (MONs) with both physical and chemical mechanisms for modulated drug delivery properties provides one solution to the extracellular stability vs. intracellular high therapeutic efficiency of MONs that hold great potential for clinical translations. EXPERIMENTS: We reported herein facile construction of diselenium-bridged MONs decorated with dual gatekeepers, i.e., azobenzene (Azo)/polydopamine (PDA) for both physical and chemical modulated drug delivery properties. Specifically, Azo can act as a...

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Dual gatekeepers-modified mesoporous organic silica nanoparticles for synergistic photothermal-chemotherapy of breast cancer

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