Zinc lactate alleviates oxidative stress by modulating crosstalk between constitutive androstane receptor signaling pathway and gut microbiota profile in weaned piglets

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成果类型：

期刊论文

作者：

Tang, Wenjie;Xiang, Xuan;Wang, Houfu;Zhou, Wentao;He, Liuqin*;...

通讯作者：

He, Liuqin;Li, TJ;He, LQ

作者机构：

[Tang, Wenjie; Yin, Yulong] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.

[Wang, Houfu; Zhou, Wentao; He, Liuqin; Xiang, Xuan; Li, Tiejun; Yin, Yulong] Chinese Acad Sci, Inst Subtrop Agr, CAS Key Lab Agro Ecol Proc Subtrop Reg, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc,, Changsha 410125, Peoples R China.

[Zhou, Wentao; He, Liuqin] Hunan Normal Univ, Coll Life Sci, Hunan Prov Key Lab Anim Intestinal Funct & Regulat, Lab Anim Nutr & Human Hlth, Changsha 410081, Peoples R China.

[Xiang, Xuan; Li, Tiejun; Yin, Yulong] Univ Chinese Acad Sci, Coll Adv Agr Sci, Beijing 100049, Peoples R China.

[Tang, Wenjie] Sichuan Acad Anim Sci, Anim Breeding & Genet Key Lab Sichuan Prov, Chengdu 610066, Peoples R China.

通讯机构：

[He, LQ; Li, TJ ] C

[He, LQ ] H

Chinese Acad Sci, Inst Subtrop Agr, CAS Key Lab Agro Ecol Proc Subtrop Reg, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc,, Changsha 410125, Peoples R China.

Hunan Normal Univ, Coll Life Sci, Hunan Prov Key Lab Anim Intestinal Funct & Regulat, Lab Anim Nutr & Human Hlth, Changsha 410081, Peoples R China.

Univ Chinese Acad Sci, Coll Adv Agr Sci, Beijing 100049, Peoples R China.

语种：

英文

关键词：

Zinc lactate;Intestinal barrier;Oxidative stress;Inflammation;Constitutive androstane receptor;Gut microbiota

期刊：

动物营养(英文)

ISSN：

2405-6545

年：

2024

卷：

页码：

23-33

DOI：

10.1016/j.aninu.2023.10.001

基金类别：

National Natural Science Foundation of China [32172755, 32130099]; Hunan Key Research and Development Plan [2022NK2023]; Shandong Province Taishan Industry Leading Talents Project Blue Talents Project

机构署名：

本校为第一机构

院系归属：

动物科学技术学院

摘要：

This study aimed to determine the regulatory mechanism of dietary zinc lactate (ZL) supplementation on intestinal oxidative stress damage in a paraquat (PQ)-induced piglet model. Twenty-eight piglets (mean body weight 9.51 +/- 0.23 kg) weaned at 28 d of age were randomly divided into control, ZL, PQ, and ZL thorn PQ groups (n 1/4 7 in each group). The ZL-supplemented diet had little effect on growth performance under normal physiological conditions. However, under PQ challenge, ZL supplementation significantly improved average daily gain (P < 0.05) and reduced the frequency of diarrhea. ZL imp...

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Zinc lactate alleviates oxidative stress by modulating crosstalk between constitutive androstane receptor signaling pathway and gut microbiota profile in weaned piglets

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