The cloning of antibody gene with high affinity is the basis for phage antibody applied in important research field of basic study and clinical diagnosis and treatment.Chain shuffling is gradually used for the improving properties of phage antibody.The technique not only facilitates affinity mature of phage antibody in vitro,broaden the prospect of application and development of antibody,but also reduces human anti-mouse antibody response,analyze effect of heavy or light chain gene on the integration of antibody and antigen,and is helpful for us to understanding immunochemistry.The paper revie...
