Analysis of the Interaction of Tarantula Toxin Jingzhaotoxin-III (β-TRTX-Cj1α) with the Voltage Sensor of Kv2.1 Uncovers the Molecular Basis for Cross-Activities on Kv2.1 and Nav1.5 Channels

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成果类型：

期刊论文

作者：

Tao, Huai;Chen, Jin J.;Xiao, Yu C.;Wu, Yuan Y.;Su, Hai B.;...

通讯作者：

Liang, SP

作者机构：

[Wang, Heng Y.; Li, Dan; Liang, Song P.; Liu, Zhong H.; Wu, Yuan Y.; Su, Hai B.; Xiao, Yu C.; Wang, Mei C.; Tao, Huai; Liang, SP] Hunan Normal Univ, Coll Life Sci, Key Lab Prot Chem & Dev Biol, Minist Educ, Changsha 410081, Hunan, Peoples R China.

[Tao, Huai] Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Changsha 410208, Hunan, Peoples R China.

[Chen, Jin J.] Hunan Agr Univ, Coll Biol Sci & Technol, Changsha 410128, Hunan, Peoples R China.

[Deng, Mel C.] Cent S Univ, Sch Biol Sci & Technol, Dept Biochem, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Liang, SP ] H

Hunan Normal Univ, Coll Life Sci, Key Lab Prot Chem & Dev Biol, Minist Educ, Changsha 410081, Hunan, Peoples R China.

语种：

英文

期刊：

BIOCHEMISTRY

ISSN：

0006-2960

年：

2013

卷：

期：

页码：

7439-7448

DOI：

10.1021/bi4006418

基金类别：

National 973 Project of China [2010CB529801]; Science Research Fund of Hunan Provincial Education Department [10B049, 10C0961]; Key Project of Chinese Ministry of Education [208096]; Huo Ying Dong Education Foundation [111023]; National Natural Science Foundation of China [31000477, 30900242, 31100764]; Academy of Finland (AKA) [111023] Funding Source: Academy of Finland (AKA)

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本校为其他机构

院系归属：

生物科学技术学院

摘要：

Animal venoms contain a fascinating array of divergent peptide toxins that have cross-activities on different types of voltage-gated ion channels. However, the underlying mechanism remains poorly understood. Jingzhaotoxin-III (JZTX-III), a 36-residue peptide from the tarantula Chilobrachys jingzhao, is specific for Nav1.5 and Kv2.1 channels over the majority of other ion channel subtypes. JZTX-III traps the Nav1.5 DII voltage sensor at closed state by binding to the DIIS3-S4 linker. In this study, electrophysiological experiments showed that JZ...

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Analysis of the Interaction of Tarantula Toxin Jingzhaotoxin-III (β-TRTX-Cj1α) with the Voltage Sensor of Kv2.1 Uncovers the Molecular Basis for Cross-Activities on Kv2.1 and Nav1.5 Channels

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