期刊论文

Wang, JQ

英文

TOXINS

2072-6651

2024

16

1

3-

10.3390/toxins16010003

Conceptualization, J.W. and R.K.; methodology, Z.L., T.C. and V.N; formal analysis, Z.W.; investigation, Z.W. and X.W.; resources, J.L. and H.T.; data curation, Z.W. and Z.L.; writing—original draft preparation, Z.W.; writing—review and editing, Z.W., X.W., T.C., V.N., B.H. and R.K.; supervision, J.W.; project administration, J.W.; funding acquisition, J.W. All authors have read and agreed to the published version of the manuscript. This work was supported by the Sino-European Cooperation Program of National Key Research and Development Program of China: no.2016YFE0113300; The Agricultural Science and Technology Innovation Program (ASTIP) from Chinese Academy of Agricultural Sciences, China: no. CAAS-IFR-ZDRW202302; and the European Union’s Horizon 2020 research and innovation program under grant agreement: no. 678012 (MyToolBox). We thank Dawei Zhang (Romer labs analytical service (Wuxi) Ltd.) for his support with the LC-MS/MS analysis of feed and serum samples.

本校为其他机构

Fumonisins (FBs), particularly fumonisin B1 (FB1) and fumonisin B2 (FB2) produced mainly by Fusarium verticillioide and Fusarium proliferatum, are common contaminants in animal feed and pose a serious threat to both animal and human health. The use of microbial enzymes to efficiently and specifically convert fumonisins into non-toxic or low-toxic metabolites has emerged as the most promising approach. However, most of the available enzymes have only been evaluated in vitro and lack systematic evaluation in vivo. In this study, the detoxification efficacy of two carboxylesterases, FumD (FUMzyme...