MiR-21 protected cardiomyocytes against doxorubicin-induced apoptosis by targeting BTG2

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tong, Zhongyi;Jiang, Bimei*;Wu, Yanyang;Liu, Yanjuan;Li, Yuanbin;...

通讯作者：

Jiang, Bimei

作者机构：

[Tong, Zhongyi] Cent S Univ, Xiangya Hosp 2, Dept Pathol, Changsha 410000, Hunan, Peoples R China.

[Xiao, Xianzhong; Li, Yuanbin; Tong, Zhongyi; Liu, Yanjuan; Lv, Qinglan; Jiang, Bimei; Gao, Min; Jiang, Yu] Cent S Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410000, Hunan, Peoples R China.

[Wu, Yanyang] Hunan Agr Univ, Food Sci & Technol Coll, Changsha 410000, Hunan, Peoples R China.

通讯机构：

[Jiang, Bimei] C

Cent S Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410000, Hunan, Peoples R China.

语种：

英文

关键词：

doxorubicin;lactate dehydrogenase;microRNA 21;antineoplastic agent;BTG2 protein, rat;doxorubicin;immediate early protein;microRNA;mirn21 microRNA, rat;tumor suppressor protein;animal cell;animal experiment;animal model;Article;cardiotoxicity;cell proliferation;cell viability;computer model;controlled study;flow cytometry;heart function;heart left ventricle enddiastolic pressure;heart muscle cell;male;mouse;nonhuman;polyacrylamide gel electrophoresis;protein expression;real time polymerase chain reaction;Western blotting;animal;apoptosis;cardiac muscle cell;cell culture;cell line;drug effects;genetics;metabolism;rat;Mus;Rattus;Animals;Antineoplastic Agents;Apoptosis;Cell Line;Cells, Cultured;Doxorubicin;Immediate-Early Proteins;Mice;MicroRNAs;Myocytes, Cardiac;Rats;Tumor Suppressor Proteins

期刊：

International Journal of Molecular Sciences

ISSN：

1661-6596

年：

2015

卷：

期：

页码：

14511-14525

DOI：

10.3390/ijms160714511

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81170113, 81071594, 81370252, 81471868, 81100106]; Ministry of Education of China for Doctoral Program [20130162130008]; Education Ministry's New Century Excellent Talents Supporting PlanProgram for New Century Excellent Talents in University (NCET) [NECT-12-0545]

机构署名：

本校为其他机构

院系归属：

食品科学技术学院

摘要：

Doxorubicin (DOX) is an anthracycline drug with a wide spectrum of antineoplastic activities. However, it causes cardiac cytotoxicity, and this limits its clinical applications. MicroRNA-21 (miR-21) plays a vital role in regulating cell proliferation and apoptosis. While miR-21 is preferentially expressed in adult cardiomyocytes and involved in cardiac development and heart disease, little is known regarding its biological functions in responding to DOX-induced cardiac cytotoxicity. In this study, the effects of DOX on mouse cardiac function an...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

MiR-21 protected cardiomyocytes against doxorubicin-induced apoptosis by targeting BTG2

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问