期刊论文

Jiang, Bimei

英文

International Journal of Molecular Sciences

1422-0067

2015

16

7

14511-14525

10.3390/ijms160714511

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81170113, 81071594, 81370252, 81471868, 81100106]; Ministry of Education of China for Doctoral Program [20130162130008]; Education Ministry's New Century Excellent Talents Supporting PlanProgram for New Century Excellent Talents in University (NCET) [NECT-12-0545]

本校为其他机构

Doxorubicin (DOX) is an anthracycline drug with a wide spectrum of antineoplastic activities. However, it causes cardiac cytotoxicity, and this limits its clinical applications. MicroRNA-21 (miR-21) plays a vital role in regulating cell proliferation and apoptosis. While miR-21 is preferentially expressed in adult cardiomyocytes and involved in cardiac development and heart disease, little is known regarding its biological functions in responding to DOX-induced cardiac cytotoxicity. In this study, the effects of DOX on mouse cardiac function and the expression of miR-21 were examined in both m...