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Metabolomics study of cat small intestine during the early stage of Toxoplasma gondii oocyst formation identifies potential biomarkers

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成果类型:
期刊论文
作者:
Zhai, Bintao;He, Jun-Jun;Xie, Shi-Chen;Qiu, Yanhua;Miao, Zengqiang;...
作者机构:
[Zhang, Jiyu; Qiu, Yanhua; Zhai, Bintao] Chinese Acad Agr Sci, Minist Agr, Lanzhou Inst Husb & Pharmaceut Sci, Key Lab Vet Pharmaceut Dev, Lanzhou 730050, Gansu, Peoples R China.
[He, Jun-Jun; Zhu, Xing-Quan] Yunnan Agr Univ, Coll Vet Med, Key Lab Vet Publ Hlth Yunnan Prov, Kunming 650201, Yunnan, Peoples R China.
[Xie, Shi-Chen; Zhu, Xing-Quan] Shanxi Agr Univ, Coll Vet Med, Taigu 030801, Shanxi, Peoples R China.
[Xie, Shi-Chen] Hunan Agr Univ, Coll Vet Med, Res Ctr Parasites & Vectors, Changsha 410128, Hunan, Peoples R China.
[Miao, Zengqiang] Qinghai Univ, Med Coll, Xining 810016, Qinghai, Peoples R China.
语种:
英文
关键词:
Biomarkers;Definitive host;Metabolomics;Toxoplasma gondii
期刊:
Veterinary Parasitology
ISSN:
0304-4017
年:
2022
卷:
309
页码:
109764
基金类别:
Youth Science and Technology Fund Program of Gansu Province [20JR5RA581]; National Natural Science Foundation of China [32172887]; Agricultural Science and Technology Innovation Program (ASTIP) [CAAS-ASTIP-2016-LVRI-03]; Fund for Shanxi "1331 Project" [20211331-13]; Central Public-interest Scientific Institution Basal Research Fund [1610322022010]; [202005AF150041]
机构署名:
本校为其他机构
院系归属:
动物医学院
摘要:
Toxoplasma gondii (T. gondii) is a zoonotic intracellular protozoan parasite that can invade, replicate and survive in almost all cells of warm-blooded animals. T. gondii infection threatens the life of the fetus or can cause morbidity in the infant. As the only definitive host of T. gondii, felids spread the pathogen mainly by forming oocysts in the small intestines and discharging the oocysts into the ambient environment, consequently polluting water, vegetables, and meat products. In this study, we used untargeted metabolomics technology to study the changes in metabolites that occurred dur...

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