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Oral Administration of Lactobacillus delbrueckii during the Suckling Phase Improves Antioxidant Activities and Immune Responses after the Weaning Event in a Piglet Model

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成果类型:
期刊论文
作者:
Li, Yinghui;Hou, Shuling;Peng, Wei;Lin, Qian;Chen, Fengming;...
通讯作者:
Huang, Xingguo
作者机构:
[Li, Yinghui; Yang, Lingyuan; Chen, Fengming; Huang, Xingguo; Peng, Wei; Hou, Shuling] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.
[Li, Yinghui; Yang, Lingyuan; Chen, Fengming; Huang, Xingguo; Peng, Wei; Hou, Shuling] CICAPS, Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Hunan, Peoples R China.
[Li, Yinghui; Yang, Lingyuan; Chen, Fengming; Huang, Xingguo; Peng, Wei; Hou, Shuling] Engn Res Ctr Feed Safety & Efficient Utilizat Edu, Changsha 410128, Hunan, Peoples R China.
[Lin, Qian] Chinese Acad Agr Sci, Inst Bast Fiber Crops, Changsha 410205, Hunan, Peoples R China.
[Li, Fengna] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Hunan, Peoples R China.
通讯机构:
[Huang, Xingguo] H
[Huang, Xingguo] C
[Huang, Xingguo] E
Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.
CICAPS, Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Hunan, Peoples R China.
语种:
英文
关键词:
Antioxidants;Body fluids;Immune system;Nitric oxide;Peptides;Probiotics;Anti-oxidant activities;Antioxidant capacity;Glutathione peroxidase;Inducible nitric oxide synthase;Inflammatory cytokines;Lactobacillus delbrueckii;Protein expressions;System functionality;Laboratories;8 hydroxydeoxyguanosine;antioxidant;biological marker;catalase;cyclooxygenase 2;fractalkine;glutathione peroxidase;hydrocortisone;inducible nitric oxide synthase;interleukin 12;interleukin 1beta;interleukin 6;macrophage inflammatory protein 3alpha;malonaldehyde;noradrenalin;probiotic agent;secretory immunoglobulin;stress hormone;animal experiment;antioxidant activity;Article;bacterial colonization;blood level;comparative study;controlled study;enzyme activity;hydrocortisone blood level;immune response;intestine mucosa;Lactobacillus delbrueckii;newborn;nonhuman;noradrenalin blood level;piglet;protein expression level;suckling animal;weaning;animal;animal model;drug effect;female;Lactobacillus delbrueckii;oral drug administration;pathogenicity;pig;weaning;Antioxidants;Capacity;Concentration;Laboratories;Management;Peptides;Phases;Administration, Oral;Animals;Female;Intestinal Mucosa;Lactobacillus delbrueckii;Models, Animal;Swine;Weaning
期刊:
Oxidative Medicine and Cellular Longevity
ISSN:
1942-0900
年:
2019
卷:
2019
页码:
6919803
基金类别:
This study was jointly supported by the National Key Research and Development Program of China (2017YF D0500506), National Natural Science Foundation of China (31772617, 31802074), Youth Science Fund Project of Hunan Agricultural University (17QN04), and Startup Scientific Research Project of Introducing Personnel in Hunan Agricultural University (540490300011).
机构署名:
本校为第一且通讯机构
院系归属:
动物科学技术学院
摘要:
Early colonization in the gut by probiotics influences the progressive development and maturity of antioxidant and immune system functionality in the future. This study investigated the impact of orally administrated Lactobacillus delbrueckii (LAB) during the suckling phase on future antioxidant and immune responses of the host, using a piglet model. One hundred neonatal piglets received saline (CON) or LAB at the amounts of 1, 2, 3, and 4 mL at 1, 3, 7, and 14 d of age, respectively. The piglets were weaned at the age of 21 d and fed until the...

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