期刊论文

Zhong, Z.

中文

中华肿瘤防治杂志

1673-5269

2010

17

14

1070-1072

10.16073/j.cnki.cjcpt.2010.14.004

本校为第一机构

目的:探讨基质金属蛋白酶(MMP-2)和Ki-67在人脑胶质瘤组织中的表达及两者之间的关系.方法:用免疫组织化学SP法检测38例人脑胶质瘤组织和7例正常人脑组织中MMP-2和Ki-67的表达.结果:正常人脑组织中无Ki-67表达,高度恶性胶质瘤(Ⅲ～Ⅳ级)中MMP-2和Ki-67的阳性表达率显著高于低级别胶质瘤组织(Ⅰ～Ⅱ级),并且两者的表达呈显著正相关性(Ki-67:Ⅲ～Ⅳ级vs Ⅰ～Ⅱ级,t=-18.889,P=0.002;MMP-2:Ⅲ～Ⅳ级vs Ⅰ～Ⅱ级,t=4.786,P=0.001;相关性:r=0.661,P=0.001).结论:MMP-2和Ki-67在恶性胶质瘤组织中高表达,与胶质瘤的进展和侵袭密切相关,可作为胶质瘤恶性表型的有用指标.

OBJECTIVE: To investigate the MMP-2 and Ki-67 in human gliomas and their relationships. METHODS: The expressions of MMP-2 and Ki-67 were detected in 38 human glioma tissues and 7 normal human brain tissues with immunohistochemical assay(SP method). RESULTS: The expressions of MMP-2 and Ki-67 in the patients with high-grade glioma were significantly higher than those in the patients with low-grade glioma and normal brain tissues, and the significant correlation was found between MMP-2 and Ki-67 (Ki-67: grade III-IV vs grade I-II, t = -18.889, P = 0.002; MMP-2: grade III-IV vs grde I-II, t = 4.7...