期刊论文

Zeng, Rui

英文

RSC Advances

2046-2069

2017

7

44

27780-27786

10.1039/c7ra03716c

Program of Study Abroad for Young Scholars - China Scholarship Council [CSC201500850007]; Sichuan Province Department of Basic Research Project [2015jy0009]; Key Technologies R & D Program of Sichuan [2014SZ0131]; National Natural Science Foundation of China [81602967]; China Postdoctoral Science Foundation [2016M592898XB]

本校为其他机构

In mammalian cells, DNA polymerase ζ (Pol ζ) catalyzes the TLS step of ICLR. By acting simultaneously with Y-family DNA polymerase, Pol ζ completes replication of damaged DNA without removing the damage by inserting a nucleotide opposite the lesion. It has been demonstrated that Pol ζ represents a promising target for the treatment of chemotherapy-resistant tumors. The first series of small-molecule inhibitors targeting REV7/REV3L interaction have been identified recently, however, their corresponding binding mechanism is not known. Herein,...