Polygonatum odoratum Polysaccharides Modulate Gut Microbiota and Mitigate Experimentally Induced Obesity in Rats

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成果类型：

期刊论文

作者：

Wang, Yan;Fei, Yanquan;Liu, Lirui;Xiao, Yunhua;Pang, Yilin;...

通讯作者：

Wang, Zheng;Kang, Jinhe

作者机构：

[Fei, Yanquan; Pang, Yilin; Wang, Zheng; Xiao, Yunhua; Wang, Yan] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

[Wang, Yan] Hunan Univ Humanities Sci & Technol, Coll Agr & Biotechnol, Loudi 417000, Peoples R China.

[Wang, Yan; Kang, Jinhe] Chinese Acad Sci, Inst Subtrop Agr,Minist Agr, CAS Key Lab Agroecol Proc Subtrop Reg,South Cent, Natl Engn Lab Pollut Control & Waste Utilizat Liv, Changsha 410125, Hunan, Peoples R China.

[Liu, Lirui] Univ Hong Kong, Sch Biol Sci, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China.

通讯机构：

[Wang, Zheng] H

[Kang, Jinhe] C

Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

Chinese Acad Sci, Inst Subtrop Agr,Minist Agr, CAS Key Lab Agroecol Proc Subtrop Reg,South Cent, Natl Engn Lab Pollut Control & Waste Utilizat Liv, Changsha 410125, Hunan, Peoples R China.

语种：

英文

关键词：

Polygonatum odoratum;gut microbiota;high-fat diet;obesity;polysaccharides

期刊：

International Journal of Molecular Sciences

ISSN：

1422-0067

年：

2018

卷：

期：

DOI：

10.3390/ijms19113587

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31071531]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [14A071]; Youth Project of Hunan Provincial Education Department [16B138]

机构署名：

本校为第一且通讯机构

院系归属：

生物科学技术学院

摘要：

Increasing evidence suggests that the gut microbiota plays vital roles in metabolic diseases. Polygonatum odoratum extract alleviates hyperglycemia and hyperlipidemia, but the underlying mechanism remains unclear. This study investigated the effects of P. odoratum polysaccharides (POPs) on high-fat diet (HFD)-induced obesity in rats and whether these effects were related to modulation of gut microbiota. POP treatment attenuated weight gain, fat accumulation, epididymal adipocyte size, liver triglycerides, and total liver cholesterol content in ...

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Polygonatum odoratum Polysaccharides Modulate Gut Microbiota and Mitigate Experimentally Induced Obesity in Rats

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