期刊论文

Wu, Jing;Wen, Lixin

英文

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

1532-0456

2019

226

108574

10.1016/j.cbpc.2019.108574

We would like to extend our gratitude to the platform and funding provided by the National Key Research and Development Program of China (Grant No. 2016YFD0501200 ), Scientific Research Foundation of Hunan Provincial Education Department (Grant No. 17B125 ), China Postdoctoral Science Foundation (Grant No. 2017M620346 ), College of Veterinary Medicine, Hunan Agricultural University , and Hunan Collaborative Innovation Center of Animal Production Safety . We would like to thank Editage [ www.editage.cn ] for English language editing.

本校为第一且通讯机构

Phenethyl isothiocyanate (PEITC) is one of the glucosinolates (GLs) present in cruciferous vegetables. Although there are many reports of livestock and poultry poisoning caused by plants containing GLs, the actual dosage that causes poisoning and the characteristics of GLs and their metabolites are unclear. Herein, we investigated the inhibitory effects of PEITC on IPEC-J2 cells and examined the mechanisms of PEITC-induced apoptosis via the mitochondrial pathway. Cell viability was determined by the MTT assay, and the levels of reactive oxygen ...