Phenethyl isothiocyanate as an anti-nutritional factor attenuates deoxynivalenol-induced IPEC-J2 cell injury through inhibiting ROS-mediated autophagy

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成果类型：

期刊论文

作者：

Liu, Shuiping;Mao, Xinru;Ge, Lei;Hou, Lili;Le, Guannan;...

通讯作者：

Huang, KH

作者机构：

[Le, Guannan; Ge, Lei; Liu, Shuiping; Huang, Kehe; Hou, Lili; Mao, Xinru; Gan, Fang] Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China.

[Le, Guannan; Ge, Lei; Liu, Shuiping; Huang, Kehe; Hou, Lili; Mao, Xinru; Gan, Fang] Nanjing Agr Univ, Inst Nutr & Metab Disorders Domest Anim & Fowls, Nanjing 210095, Peoples R China.

[Le, Guannan; Ge, Lei; Liu, Shuiping; Huang, Kehe; Hou, Lili; Mao, Xinru; Gan, Fang] Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing 210095, Peoples R China.

[Wen, Lixin] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

通讯机构：

[Huang, KH ] N

Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China.

Nanjing Agr Univ, Inst Nutr & Metab Disorders Domest Anim & Fowls, Nanjing 210095, Peoples R China.

Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing 210095, Peoples R China.

语种：

英文

关键词：

Deoxynivalenol;Phenethyl isothiocyanate;Autophagy;Oxidative damage;Porcine intestinal epithelial cell

期刊：

动物营养(英文)

ISSN：

2405-6545

年：

2022

卷：

期：

页码：

300-309

DOI：

10.1016/j.aninu.2021.09.013

基金类别：

This study was financially supported by the National Natural Science Foundation of China ( 32072926 , 31772811 ) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (Jiangsu, China) .

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

Deoxynivalenol (DON) is considered to be the most harmful mycotoxin that affects the intestinal health of animals and humans. Phenethyl isothiocyanate (PEITC) in feedstuff is an anti-nutritional factor and impairs nutrient digestion and absorption in the animal intestinal. In the current study, we aimed to explore the effects of PEITC on DON-induced apoptosis, intestinal tight junction disorder, and its potential molecular mechanism in the porcine jejunum epithelial cell line (IPEC-J2). Our results indicated that PEITC treatment markedly allevi...

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Phenethyl isothiocyanate as an anti-nutritional factor attenuates deoxynivalenol-induced IPEC-J2 cell injury through inhibiting ROS-mediated autophagy

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