期刊论文

Wang, J

英文

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

1532-0456

2024

276

109804

10.1016/j.cbpc.2023.109804

This work was supported by the National Key Research and Development Program of China [grant number 2016YDF0501200]; and the Frontier Key Science and Technology Research in the Pig Industry [grant number 2019xny-js044]. CRediT authorship contribution statement Yuanyuan Zhu: Conceptualization, Formal analysis, Writing – original draft. Qiurong Xu: Methodology, Writing – original draft. Ruili Zou: Methodology. Ran Tao: Formal analysis. Shuiping Liu: Visualization. Xiaowen Li: Data curation. Lixin Wen: acquisition, Supervision. Jing Wu: Conceptualization, Writing – review & editing. Ji Wang: Project administration, Visualization, Writing – review & editing.

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Glucosinolates (GLS) in cruciferous vegetables are anti-nutritional factors. Excessive or long-term intake of GLS-containing feed is harmful to animal health and may cause kidney damage. Phenethyl isothiocyanate (PEITC) is a GLS. In this study, we investigated the inhibitory effect of PEITC on a porcine kidney (PK-15) cell line and explored the mechanism of PEITC-induced apoptosis. We found that PEITC could affect cell viability and induce cell apoptosis after incubating cells for 24h. High concentrations of PEITC can induce intracellular ROS a...