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Inhibitory effects and molecular mechanisms of garlic organosulfur compounds on the production of inflammatory mediators

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成果类型:
期刊论文
作者:
You, Sixiang;Nakanishi, Eri;Kuwata, Hiroko;Chen, Jihua;Nakasone, Yasushi;...
通讯作者:
Hou, De-Xing
作者机构:
[Zhang, Shirui; He, Xi; You, Sixiang; Zhang, Bin; Hou, De-Xing; He, Jianhua] Hunan Agr Univ, Educ Minist, Engn Res Ctr Feed Safety & Efficient Utilizat, Changsha, Hunan, Peoples R China.
[Nakanishi, Eri; Chen, Jihua; You, Sixiang; Kuwata, Hiroko; Hou, De-Xing] Kagoshima Univ, Fac Agr, Dept Biochem Sci & Technol, Kagoshima 8900065, Japan.
[Liu, Xiangxin; You, Sixiang] Hunan Agr Univ, Coll Anim Med, Changsha, Hunan, Peoples R China.
[Nakasone, Yasushi] Kenkoukazoku Co, Kagoshima, Japan.
[Hou, De-Xing; He, Jianhua] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Changsha, Hunan, Peoples R China.
通讯机构:
[Hou, De-Xing] K
Kagoshima Univ, Fac Agr, Korimoto 1-21-24, Kagoshima 8900065, Japan.
语种:
英文
关键词:
allyl compound;antiinflammatory agent;cyclooxygenase 2;diallyl trisulfide;heme oxygenase 1;Hmox1 protein, mouse;immunoglobulin enhancer binding protein;inducible nitric oxide synthase;interleukin 10;interleukin 12;interleukin 6;lipopolysaccharide;MAP kinase kinase kinase 7;membrane protein;mitogen activated protein kinase;mitogen activated protein kinase kinase kinase;Nfe2l2 protein, mouse;Nos2 protein, mouse;Nqo1 protein, mouse;plant extract;prostaglandin E2;protein kinase B;Ptgs2 protein, mouse;reactive oxygen metabolite;reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone);sulfide;transcription factor Nrf2;transforming growth factor beta;tumor necrosis factor alpha;animal;article;chemistry;disease model;down regulation;drug antagonism;drug effect;edema;garlic;Garlic organosulfur compounds;inflammation;Inflammatory mediators;MAPK;metabolism;mouse;NF-κB;phosphorylation;signal transduction;TGF-β-activated kinase;tumor cell line;Garlic organosulfur compounds;Inflammatory mediators;MAPK;NF-κB;TGF-β-activated kinase;Allyl Compounds;Animals;Anti-Inflammatory Agents;Cell Line, Tumor;Cyclooxygenase 2;Dinoprostone;Disease Models, Animal;Down-Regulation;Edema;Garlic;Heme Oxygenase-1;Inflammation;Interleukin-10;Interleukin-12;Interleukin-6;Lipopolysaccharides;MAP Kinase Kinase Kinases;Membrane Proteins;Mice;Mitogen-Activated Protein Kinases;NAD(P)H Dehydrogenase (Quinone);NF-E2-Related Factor 2;NF-kappa B;Nitric Oxide Synthase Type II;Phosphorylation;Plant Extracts;Proto-Oncogene Proteins c-akt;Reactive Oxygen Species;Signal Transduction;Sulfides;Transforming Growth Factor beta;Tumor Necrosis Factor-alpha
期刊:
MOLECULAR NUTRITION & FOOD RESEARCH
ISSN:
1613-4125
年:
2013
卷:
57
期:
11
页码:
2049-2060
基金类别:
Hunan Agriculture University grant for 100 Intelligent
机构署名:
本校为第一机构
院系归属:
园艺园林学院
动物科学技术学院
动物医学院
摘要:
Scope: Garlic is used for both culinary and medicinal purposes by many cultures. The garlic organosulfur compounds (GOSCs) are thought to be bioactive components. This study aims to clarify the antiinflammatory effects and molecular mechanisms of GOSCs in both cell and animal models. Methods and results: RAW264.7 cells were treated with six kinds of GOSCs to screen their influence on cyclooxygenase-2 and inducible nitric oxide synthase expression by Western blotting. Prostaglandin E2 and nitrite were measured by ELISA and Griess reaction, respe...

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