Inhibitory effects and molecular mechanisms of garlic organosulfur compounds on the production of inflammatory mediators

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

You, Sixiang;Nakanishi, Eri;Kuwata, Hiroko;Chen, Jihua;Nakasone, Yasushi;...

通讯作者：

Hou, De-Xing

作者机构：

[Zhang, Shirui; He, Xi; You, Sixiang; Zhang, Bin; Hou, De-Xing; He, Jianhua] Hunan Agr Univ, Educ Minist, Engn Res Ctr Feed Safety & Efficient Utilizat, Changsha, Hunan, Peoples R China.

[Nakanishi, Eri; Chen, Jihua; You, Sixiang; Kuwata, Hiroko; Hou, De-Xing] Kagoshima Univ, Fac Agr, Dept Biochem Sci & Technol, Kagoshima 8900065, Japan.

[Liu, Xiangxin; You, Sixiang] Hunan Agr Univ, Coll Anim Med, Changsha, Hunan, Peoples R China.

[Nakasone, Yasushi] Kenkoukazoku Co, Kagoshima, Japan.

[Hou, De-Xing; He, Jianhua] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Changsha, Hunan, Peoples R China.

通讯机构：

[Hou, De-Xing] K

Kagoshima Univ, Fac Agr, Korimoto 1-21-24, Kagoshima 8900065, Japan.

语种：

英文

关键词：

Garlic organosulfur compounds;Inflammatory mediators;MAPK;NF-κB;TGF-β-activated kinase

期刊：

MOLECULAR NUTRITION & FOOD RESEARCH

ISSN：

1613-4125

年：

2013

卷：

期：

页码：

2049-2060

DOI：

10.1002/mnfr.201200843

基金类别：

Hunan Agriculture University; International Science & Technology Cooperation Program of China [2011DFA30490]; Scholar Research of Kagoshima University, Japan

机构署名：

本校为第一机构

院系归属：

园艺园林学院

动物科学技术学院

动物医学院

摘要：

Scope: Garlic is used for both culinary and medicinal purposes by many cultures. The garlic organosulfur compounds (GOSCs) are thought to be bioactive components. This study aims to clarify the antiinflammatory effects and molecular mechanisms of GOSCs in both cell and animal models. Methods and results: RAW264.7 cells were treated with six kinds of GOSCs to screen their influence on cyclooxygenase-2 and inducible nitric oxide synthase expression by Western blotting. Prostaglandin E2 and nitrite were measured by ELISA and Griess reaction, respe...

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Inhibitory effects and molecular mechanisms of garlic organosulfur compounds on the production of inflammatory mediators

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