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Bioactive Components From Gracilaria rubra With Growth Inhibition on HCT116 Colon Cancer Cells and Anti-inflammatory Capacity in RAW 264.7 Macrophages

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成果类型:
期刊论文
作者:
Yi, Lingxiao;Wang, Qi;Luo, Haiyan;Lei, Daqing;Tang, Zhonghai;...
通讯作者:
Xiao, H;Lei, SJ;Tang, ZH
作者机构:
[Luo, Haiyan; Yi, Lingxiao; Xiao, Hang; Xiao, H; Wang, Qi] Univ Massachusetts, Dept Food Sci, Amherst, MA USA.
[Lei, Sijia; Lei, Daqing; Lei, SJ] Shenzhen Polytech, Sch Food & Drug, Shenzhen, Peoples R China.
[Tang, Zhonghai] Hunan Agr Univ, Coll Food Sci & Technol, Changsha, Peoples R China.
通讯机构:
[Lei, SJ ] S
[Xiao, H ] U
[Tang, ZH ] H
Univ Massachusetts, Dept Food Sci, Amherst, MA USA.
Shenzhen Polytech, Sch Food & Drug, Shenzhen, Peoples R China.
语种:
英文
关键词:
Gracilaria rubra;Extractable components;non-extractable components;Anti-colon cancer;anti-inflammation
期刊:
FRONTIERS IN NUTRITION
ISSN:
2296-861X
年:
2022
卷:
9
页码:
856282
基金类别:
This study was partially supported by the Shenzhen Strategic Emerging Industry Development Special Fund Project (Shenzhen Municipal Economic and Trade Information Commission, #20180130150742764 to SL), United States Department of Agriculture (MAS00450 and MAS00492, and NIFA grant #2019-67017-29249 and 2020-67017-30835 to HX), Hunan Science and Technology Plan Program (2019RS1055 to ZT), and Major Research plan of Changsha (kq1801016 to ZT).
机构署名:
本校为通讯机构
院系归属:
食品科学技术学院
摘要:
Gracilaria rubra is rich in bioactive compounds with various potential health benefits. This study aimed to elucidate the profile of both extractable bioactive components (EBCs) and non-extractable bioactive components (NEBCs) of G. rubra and determine their anti-colon cancer and anti-inflammatory activities. Both EBCs and NEBCs displayed strong suppressive effects on the viability of HCT116 cells, which causes cell cycle arrest, induces cellular apoptosis, and regulates the expression of cyclin-dependent kinases (CDKs) and tumor suppressor pro...

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