Highly efficient cellular uptake of a cell-penetrating peptide (CPP) derived from the capsid protein of porcine circovirus type 2

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成果类型：

期刊论文

作者：

Yu, Wanting;Zhan, Yang;Xue, Boxin;Dong, Yanpeng;Wang, Yanfeng;...

通讯作者：

Yang, Yi;Sun, Yujie

作者机构：

[Zhan, Yang; Wang, Aibing; Yu, Wanting; Yang, Yi] Hunan Agr Univ, Coll Vet Med, Key Lab Anim Vaccine & Prot Engn, Changsha 410128, Hunan, Peoples R China.

[Zhan, Yang; Wang, Aibing; Yu, Wanting; Yang, Yi] Hunan Agr Univ, Coll Vet Med, LFP, Changsha 410128, Hunan, Peoples R China.

[Zhan, Yang; Wang, Aibing; Yu, Wanting; Yang, Yi] Hunan Agr Univ, Coll Vet Med, RCRV, Changsha 410128, Hunan, Peoples R China.

[Xue, Boxin; Sun, Yujie] Peking Univ, Sch Life Sci, Biodynam Opt Imaging Ctr BIOPIC, State Key Lab Membrane Biol, Beijing 100871, Peoples R China.

[Jiang, Ping; Dong, Yanpeng] Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China.

通讯机构：

[Yang, Yi] H

[Sun, Yujie] P

Hunan Agr Univ, Coll Vet Med, LFP, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Coll Vet Med, RCRV, Changsha 410128, Hunan, Peoples R China.

Peking Univ, Sch Life Sci, Biodynam Opt Imaging Ctr BIOPIC, State Key Lab Membrane Biol, Beijing 100871, Peoples R China.

语种：

英文

关键词：

*Circoviridae;*capsid protein;*cell-penetrating peptide (CPP);*cellular uptake;*endocytosis;*intracellular trafficking;*membrane;*membrane permeability;*nuclear localization signal (NLS);*permeability;*porcine circovirus virus (PCV);*protein delivery;*transport vector

期刊：

Journal of Biological Chemistry

ISSN：

0021-9258

年：

2018

卷：

293

期：

页码：

15221-15232

DOI：

10.1074/jbc.RA118.004823

基金类别：

National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31270819, 31571432, 21573013]; National Key Research and Development Program of China [2017YFA0505300]; Talent Input Project of Hunan Agricultural University [540490317006]; Hunan Provincial Key Laboratory of Protein Engineering in Animal Vaccines [2017TP1014]

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Porcine circovirus type 2 (PCV2) is one of the smallest, nonenveloped, single-stranded DNA viruses. The PCV2 capsid protein (Cap) is the sole viral structural protein and main antigenic determinant. Previous sequence analysis has revealed that theN terminus of the PCV2 Cap contains a nuclear localization signal (NLS) enriched in positively charged residues. Here, we report that PCV2' s NLS can function as a cell-penetrating peptide (CPP). We observed that this NLS can carry macromolecules, e.g. enhanced GFP (EGFP), into cells when they are fuse...

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Highly efficient cellular uptake of a cell-penetrating peptide (CPP) derived from the capsid protein of porcine circovirus type 2

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