Synergistic effects of l-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation

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成果类型：

期刊论文

作者：

Xu, Wei;Song, Xianying;Qu, Qingyun;Gong, Zhihua;Xiao, Wenjun

通讯作者：

Gong, Zhihua(gzh041211@163.com);Xiao, Wenjun(xiaowenjun88@sina.com)

作者机构：

[Song, Xianying; Gong, Zhihua; Qu, Qingyun; Xiao, Wenjun; Xu, Wei] Hunan Agr Univ, Minist Educ, Key Lab Tea Sci, Changsha 410128, Hunan, Peoples R China.

[Song, Xianying; Gong, Zhihua; Qu, Qingyun; Xiao, Wenjun; Xu, Wei] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingre, Changsha 410128, Hunan, Peoples R China.

[Song, Xianying; Gong, Zhihua; Qu, Qingyun; Xiao, Wenjun; Xu, Wei] Coinnovat Ctr Educ Minist Utilizat Bot Funct Ingre, Changsha, Peoples R China.

[Song, Xianying; Gong, Zhihua; Qu, Qingyun; Xiao, Wenjun; Xu, Wei] Hunan Agr Univ, Hunan Collaborat Innovat Ctr Utilizat Bot Funct In, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Zhihua Gong; Wenjun Xiao] K

Key Lab of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, Hunan 410128, China<&wdkj&>National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, Hunan 410128, China<&wdkj&>Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, China<&wdkj&>Hunan Agricultural University, Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, Changsha, Hunan 410128, China

语种：

英文

期刊：

FOOD & FUNCTION

ISSN：

2042-6496

年：

2023

卷：

期：

页码：

2059-2073

DOI：

10.1039/d2fo03404b

基金类别：

This work was supported by The National Natural Science Foundation of China (No. 31871804), the National Key Research and Development Program of China (No. 2022YFD1600805), and the Major Science and Technology Project of Hunan Province (No. 2021NK1020). The authors thank Editage for English language editing.

机构署名：

本校为第一机构

院系归属：

园艺园林学院

摘要：

Ovalbumin (OVA), a commonly consumed food protein, can cause severe allergies and intestinal immune disorders. l-Theanine (LTA) and epigallocatechin gallate (EGCG) regulate intestinal immunity. However, it is unclear whether an LTA and EGCG combined intervention can alleviate OVA allergy (OVA-A) by modulating intestinal-specific immunity, and it is unknown whether there is a synergistic effect between LTA and EGCG. Therefore, we treated BALB/c OVA-sensitized mice with LTA, EGCG, or a combination of both (LTA + EGCG) to investigate the effects o...

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Synergistic effects of l-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation

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