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Sirtuin 3 Restores Synthesis and Secretion of Very Low-Density Lipoproteins in Cow Hepatocytes Challenged with Nonesterified Fatty Acids In Vitro

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成果类型:
期刊论文
作者:
Xing, Dongmei;Wang, Baogen;Lu, Hong;Peng, Tao;Su, Jianming;...
通讯作者:
Lei Liu<&wdkj&>Yingfang Zhou
作者机构:
[Lu, Hong; Zhou, Yingfang; Wang, Baogen; Peng, Tao; Lei, Hongyu; Xing, Dongmei; Liu, Lei; Su, Jianming] Hunan Agr Univ, Coll Vet Med, Hunan Prov Key Lab Prot Engn Anim Vaccines, Changsha 410128, Peoples R China.
[He, Jianhua] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.
通讯机构:
[Lei Liu; Yingfang Zhou] A
Authors to whom correspondence should be addressed.<&wdkj&>Hunan Provincial Key Laboratory of Protein Engineering in Animal Vaccines, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China
语种:
英文
关键词:
animal metabolic diseases;fat metabolism;MTP;ApoB100;ApoE;perinatal period
期刊:
Veterinary Sciences
ISSN:
2306-7381
年:
2021
卷:
8
期:
7
页码:
121-
基金类别:
Conceptualization, Y.Z. and L.L.; methodology, D.X., B.W., H.L. (Hong Lu), T.P., J.S. and H.L. (Hongyu Lei); validation, Y.Z. and L.L.; formal analysis, L.L. and J.H.; investigation, D.X., B.W., H.L (Hong Lu). and T.P.; data curation, D.X., J.H. and L.L.; writing—original draft preparation, L.L.; writing—review and editing, J.S. and H.L. (Hongyu Lei); visualization, D.X. and L.L.; supervision, L.L.; project administration, Y.Z. and L.L.; funding acquisition, L.L. All authors have read and agreed to the published version of the manuscript. This research was funded by the Science Fund for Distinguished Young Scholars of Changsha City, grant number kq2009055, and the Scientific Research Foundation for the introduction of talent in Hunan Agricultural University, grant number 15YJ05.
机构署名:
本校为第一机构
院系归属:
动物科学技术学院
动物医学院
摘要:
Fatty liver is closely associated with elevated concentrations of nonesterified fatty acids (NEFA) and a low level of very low-density lipoproteins (VLDL) in blood of dairy cows. High NEFA inhibit the VLDL synthesis and assembly, and cause hepatic triacylglycerol (TAG) deposition. Sirtuin 3 (SIRT3), a mitochondrial deacetylase, antagonizes NEFA-induced TAG accumulation through modulating expressions of fatty acid synthesis and oxidation genes in cow hepatocytes. However, the role of SIRT3 in the VLDL synthesis and assembly was largely unknown. Here we aimed to test whether SIRT3 would recover ...

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