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Protective effects of betulinic acid on intestinal mucosal injury induced by cyclophosphamide in mice.

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成果类型:
期刊论文
作者:
Wang, Xihong;Yuan, Zhihang;Zhu, Lijuan;Yi, Xianglian;Ou, Zhaoping;...
通讯作者:
Wu, Jing;Yi, Jine
作者机构:
[Tan, Zhuliang; Wu, Jing; Wang, Xihong; Ou, Zhaoping; Yi, Xianglian; Li, Rongfang; Zhu, Lijuan; Yi, Jine; Yuan, Zhihang; Yi, JN] Hunan Agr Univ, Coll Vet Med, Changsha, Hunan, Peoples R China.
[Pozniak, Blazej; Obminska-Mrukowicz, Bozena] Wroclaw Univ Environm & Life Sci, Fac Vet Med, Dept Pharmacol & Toxicol, Wroclaw, Poland.
通讯机构:
[Wu, J; Yi, JN] H
Hunan Agr Univ, Coll Vet Med, Changsha, Hunan, Peoples R China.
语种:
英文
关键词:
betulic acid;claudin 1;cyclophosphamide;glutathione;interleukin 10;interleukin 17;interleukin 1beta;interleukin 2;interleukin 5;macrophage inflammatory protein 1alpha;macrophage inflammatory protein 1beta;malonaldehyde;messenger RNA;protein ZO1;superoxide dismutase;tumor necrosis factor;antioxidant;betulic acid;cyclophosphamide;cytokine;nonsteroid antiinflammatory agent;triterpene;animal experiment;animal model;antioxidant activity;Article;controlled study;down regulation;drug mechanism;enzyme activity;enzyme inhibition;intestine injury;intestine mucosa;intestine villus;male;morphology;mouse;nonhuman;protein expression;regulatory mechanism;reverse transcription polymerase chain reaction;small intestine;treatment duration;animal;drug effect;immunology;inbred mouse strain;intestine mucosa;metabolism;oxidation reduction reaction;oxidative stress;pathology;Animals;Anti-Inflammatory Agents, Non-Steroidal;Antioxidants;Cyclophosphamide;Cytokines;Intestinal Mucosa;Intestine, Small;Male;Mice, Inbred Strains;Oxidation-Reduction;Oxidative Stress;Triterpenes
期刊:
Pharmacological Reports
ISSN:
1734-1140
年:
2019
卷:
71
期:
5
页码:
929-939
基金类别:
We are grateful for the financial support from the Education Department of Hunan Province, China ( 17A098 and 17B125 ), Hunan Provincial Innovation Foundation for Postgraduate, China ( CX2018B411 ) and China Postdoctoral Science Foundation ( 2017M620346 ).
机构署名:
本校为第一且通讯机构
院系归属:
动物医学院
摘要:
Background: Betulinic acid (BA) is a plant-derived pentacyclic triterpenoid with a variety of biological activities. The purpose of this study was to assess the potential protective role of BA against intestinal mucosal injury induced by cyclophosphamide (CYP) treatment. Methods: Mice were pretreated with BA daily (0.05, 0.5, and 5.0 mg/kg) for 14 days, then injected intraperitoneally with CYP (50 mg/kg) for 2 days. Results: BA pretreatment reduced the contents of malondialdehyde (MDA) and glutathione (GSH), decreased the activity of superoxide...

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