Characterization of absorbed and produced constituents in goat plasma urine and faeces from the herbal medicine Gelsemium elegans by using high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

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期刊论文

作者：

Zuo, Meng-Ting;Wang, Zi-Yuan;Yang, Kun;Li, Yu-Juan;Huang, Chong-Ying;...

通讯作者：

Liu, Zhao-Ying

作者机构：

[Huang, Chong-Ying; Yu, Hui; Wang, Zi-Yuan; Zhao, Xue-Jiao; Li, Yu-Juan; Yang, Kun; Liu, Zhao-Ying; Liu, Yan-Chun; Zuo, Meng-Ting] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Huang, Chong-Ying; Yu, Hui; Wang, Zi-Yuan; Zhao, Xue-Jiao; Li, Yu-Juan; Liu, Zhao-Ying; Liu, Yan-Chun; Zuo, Meng-Ting] Hunan Agr Univ, Hunan Engn Technol Res Ctr Vet Drugs, Changsha 410128, Hunan, Peoples R China.

[Liu, Zhao-Ying] Hunan Agr Univ, Hunan Key Lab Tradit Chinese Vet Med, Changsha 410128, Hunan, Peoples R China.

[Liu, Zhao-Ying] Hunan Agr Univ, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Liu, Zhao-Ying] H

Hunan Agr Univ, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

11 hydroxygelsenicine;11,14 dihydroxygelsenicine;14 acetoxy 15 hydroxygelsenicine;14 acetoxygelsenicine;14 hydroxy 19 oxogelsenicine;14 hydroxygelsenicine;14 hydroxyrankinidine;15 hydroxyhumantenoxenine;16 epi voacarpine;19 oxogelsencine;21 oxogelsemine;21 oxogelsevirine;3 hydroxykoumidine;alkaloid derivative;drug metabolite;gardnerine;gelsedine;gelsemine;gelsemium elegans extract;gelsemolenine b;gelsenicine;humantenmine;hydroxydihydrogelsemine;iridoid;koumine;oxokoumidine;plant extract;sarpagine;triterpene;unclassified drug;unindexed drug;plant extract;animal experiment;Article;chemical composition;comparative study;controlled study;dehydrogenation;demethylation;drug glucuronidation;drug metabolism;feces;feces analysis;Gelsemium;gelsemium elegans;herbal medicine;high performance liquid chromatography;hydrogenation;male;nonhuman;oxidation;quadrupole mass spectrometry;single drug dose;time of flight mass spectrometry;urine;urine sampling;animal;blood;chemistry;Chinese medicine;goat;high performance liquid chromatography;intestine absorption;mass spectrometry;Animals;Chromatography, High Pressure Liquid;Feces;Gelsemium;Goats;Intestinal Absorption;Male;Mass Spectrometry;Medicine, Chinese Traditional;Plant Extracts

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2020

卷：

252

页码：

112617

DOI：

10.1016/j.jep.2020.112617

基金类别：

This work was supported by National Natural Science Foundation of China (Grant No.31972737), Scientific Research Fund of Hunan Provincial Education Department (Grant No. 18A088) and Double first-class construction project of Hunan Agricultural University (No.kxk201801008). Acknowledgments to Hunan Zhong Renpengcai Agriculture and Animal Husbandry Technology Development Co. Ltd. (Changsha, China) for kindly provided samples of goats. This work was supported by National Natural Science Foundation of China (Grant No. 31972737 ), Scientific Research Fund of Hunan Provincial Education Department (Grant No. 18A088 ) and Double first-class construction project of Hunan Agricultural University (No. kxk201801008 ). Acknowledgments to Hunan Zhong Renpengcai Agriculture and Animal Husbandry Technology Development Co., Ltd. (Changsha, China) for kindly provided samples of goats.

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Ethnopharmacological relevance: Herbal medicine contains hundreds of natural products, and studying their absorption, metabolism, distribution, and elimination presents great challenges. Gelsemium elegans (G. elegans) is a flowering plants in the Loganiaceae family. The plant is known to be toxic and has been used for many years as a traditional Chinese herbal medicine for the treatment of rheumatoid arthritis, neuropathic pain, spasticity, skin ulcers and cancer. It was also used as veterinary drugs for deworming, promoting animal growth, and ...

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Characterization of absorbed and produced constituents in goat plasma urine and faeces from the herbal medicine Gelsemium elegans by using high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

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