TRIM103 activates the RLRs pathway to enhance antiviral response by targeting VP5 and VP7.

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成果类型：

期刊论文

作者：

Qin, Beibei;Lv, Zhao;Yang, Hong;Xiao, Tiaoyi;Su, Jianming*

通讯作者：

Su, Jianming

作者机构：

[Qin, Beibei] College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China

[Lv, Zhao; Yang, Hong; Xiao, Tiaoyi] Fisheries College, Hunan Agricultural University, Changsha, 410128, China

[Lv, Zhao; Xiao, Tiaoyi] Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agricultural University, Changsha, 410128, China

[Su, Jianming] Department of Basic Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China. Electronic address: sjmauhn@hunau.edu.cn

通讯机构：

[Su, Jianming] D

Department of Basic Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China. Electronic address:

语种：

英文

关键词：

Antiviral immunity;B30.2 domain;Grass carp;Tripartite motif proteins

期刊：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

ISSN：

0145-305X

年：

2024

卷：

161

页码：

105254

DOI：

10.1016/j.dci.2024.105254

机构署名：

本校为第一且通讯机构

院系归属：

动物科学技术学院

动物医学院

摘要：

Grass carp (Ctenopharyngodon idella), crucial to global inland aquaculture with a production of 5.8 million tones in 2020, faces significant challenges from hemorrhagic disease caused by grass carp reovirus (GCRV). Rapid mutations compromise current vaccines, underscoring the need for a deeper understanding of antiviral mechanisms to enhance molecular marker-assisted selection. This study investigates the role of Tripartite Motif (TRIM) family in the innate immune response of grass carp, focusing on TRIM103 from Ctenopharyngodon Idella (CiTRIM103), a member of the TRIM-B30.2 family, which incl...

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TRIM103 activates the RLRs pathway to enhance antiviral response by targeting VP5 and VP7.

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