期刊论文

Liu, Hu-Hu(liuhuhu@hunau.edu.cn)

英文

Bioresource Technology

0960-8524

2022

363

127862

10.1016/j.biortech.2022.127862

CRediT authorship contribution statement Xi-Yu Duan: Conceptualization, Methodology, Data curation, Writing – original draft. Yun Tian: Resources, Writing – review & editing. Ze-Qi Song: Methodology, Data curation. Li-Ping Song: Methodology, Data curation. Wen-Bo Lin: Formal analysis. Chong Wang: Formal analysis. Hui Yang: Validation, Formal analysis. Xiang-Yang Lu: Formal analysis, acquisition. Xiao-Jun Ji: Resources, Validation. Hu-Hu Liu: acquisition, Supervision, Writing – review & editing.

本校为第一机构

Cordycepin is a nucleoside antibiotic with various biological activities, which has wide applications in the area of cosmetic and medicine industries. However, the current production of cordycepin is costly and time-consuming. To construct the promising cell factory for high-level cordycepin production, firstly, the design and construction of cordycepin biosynthetic pathway were performed in Yarrowia lipolytica. Secondly, the adaptivity between cordycepin biosynthetic pathway and Y. lipolytica was enhanced by enzyme fusion and integration site ...