Adopting the multiple regression method, the study conducts a research into the influence of the four factors of academic litera-ture characteristics such as the research object, on the novelty of sci-tech novelty search projects. It is found that there is a strong linear correlation between the research contents, research methods and research results and the novelty judgment of sci-tech novelty search pro-jects. A multiple regression model is obtained, and the results are inspected and analyzed as well. The model can be used to quantitatively judge on the science and technology novelty of nov...