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Isolation of Dihydroartemisinic Acid from Artemisia annua L. By-Product by Combining Ultrasound-Assisted Extraction with Response Surface Methodology

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成果类型:
期刊论文
作者:
Liu, Shuoqian;Ferreira, Jorge Freire da Silva;Liu, Liping;Tang, Yuwei;Tian, Dongming;...
通讯作者:
Tian, Na
作者机构:
[Tian, Na; Liu, Zhonghua; Liu, Shuoqian; Liu, Liping; Tang, Yuwei] Hunan Agr Univ, Dept Tea Sci, Coll Hort & Hardening, Changsha 410128, Hunan, Peoples R China.
[Tian, Dongming; Liu, Zhonghua; Liu, Shuoqian] Natl Res Ctr Engn Technol Utilizat Funct Ingredie, Changsha 410128, Hunan, Peoples R China.
[Ferreira, Jorge Freire da Silva] ARS, US Salin Lab, USDA, Riverside, CA 92507 USA.
通讯机构:
[Tian, Na] H
Hunan Agr Univ, Dept Tea Sci, Coll Hort & Hardening, Changsha 410128, Hunan, Peoples R China.
语种:
英文
关键词:
dihydroartemisinic acid;ultrasound-assisted extraction;response surface;Artemisia annua L.;alkaline extraction;acid precipitation
期刊:
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN:
0009-2363
年:
2017
卷:
65
期:
8
页码:
746-753
基金类别:
National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31501367, 31270335]; International Science & Technology Cooperation Program of China [2014DFA32160]
机构署名:
本校为第一且通讯机构
院系归属:
园艺园林学院
摘要:
Malaria is the most devastating parasitic disease worldwide. Artemisinin is the only drug that can cure malaria that is resistant to quinine-derived drugs. After the commercial extraction of artemisinin from Artemisia annua, the recovery of dihydroartemisinic acid (DHAA) from artemisinin extraction by-product has the potential to increase artemisinin commercial yield. Here we describe the development and optimization of an ultrasound-assisted alkaline procedure for the extraction of DHAA from artemisinin production waste using response surface ...

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