An analytical strategy to explore the multicomponent pharmacokinetics of herbal medicine independently of standards: Application in Gelsemium elegans extracts

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yang, Kun;Long, Xue-Ming;Cao, Jun-Jie;Li, Yu-Juan;Wu, Yong;...

通讯作者：

Sun, Zhi-Liang;Liu, Zhao-Ying

作者机构：

[Wu, Yong; Bai, Xia; Li, Yu-Juan; Sun, Zhi-Liang; Yang, Kun; Liu, Zhao-Ying; Cao, Jun-Jie] Hunan Agr Univ, Hunan Engn Technol Res Ctr Vet Drugs, Changsha 410128, Hunan, Peoples R China.

[Wu, Yong; Bai, Xia; Li, Yu-Juan; Sun, Zhi-Liang; Yang, Kun; Liu, Zhao-Ying; Cao, Jun-Jie] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Long, Xue-Ming] Hunan Prov Inst Vet Drugs & Feed Control, Changsha 410006, Hunan, Peoples R China.

[Sun, ZL; Liu, Zhao-Ying] Hunan Agr Univ, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Sun, ZL; Liu, ZY] H

Hunan Agr Univ, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Alkaloids;Gelsemium elegans;Herbal medicine;LC-MS/MS;Pharmacokinetics

期刊：

Journal of Pharmaceutical and Biomedical Analysis

ISSN：

0731-7085

年：

2019

卷：

176

页码：

112833

DOI：

10.1016/j.jpba.2019.112833

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31972737]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2017111017]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [15B114, 18A088]

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

The multicomponent pharmacokinetic study of herbal medicine is a great challenge due to the low plasma concentrations, large range of concentration scales, lack of authentic standards and uncertain interactions of the components. The aim of this work was to explore the in vivo pharmacokinetics of herbal medicine independently of authentic standards using an integrated analytical strategy. First, ion pairs of multiple components were tuned and selected, and then major parameters were optimized for derivative multiple reaction monitoring (DeMRM) by LC-MS/MS, which was combined with characterizat...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

An analytical strategy to explore the multicomponent pharmacokinetics of herbal medicine independently of standards: Application in Gelsemium elegans extracts

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问