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An analytical strategy to explore the multicomponent pharmacokinetics of herbal medicine independently of standards: Application in Gelsemium elegans extracts

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成果类型:
期刊论文
作者:
Yang, Kun;Long, Xue-Ming;Cao, Jun-Jie;Li, Yu-Juan;Wu, Yong;...
通讯作者:
Sun, Zhi-Liang;Liu, Zhao-Ying
作者机构:
[Wu, Yong; Bai, Xia; Li, Yu-Juan; Sun, Zhi-Liang; Yang, Kun; Liu, Zhao-Ying; Cao, Jun-Jie] Hunan Agr Univ, Hunan Engn Technol Res Ctr Vet Drugs, Changsha 410128, Hunan, Peoples R China.
[Wu, Yong; Bai, Xia; Li, Yu-Juan; Sun, Zhi-Liang; Yang, Kun; Liu, Zhao-Ying; Cao, Jun-Jie] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.
[Long, Xue-Ming] Hunan Prov Inst Vet Drugs & Feed Control, Changsha 410006, Hunan, Peoples R China.
[Sun, ZL; Liu, Zhao-Ying] Hunan Agr Univ, Changsha 410128, Hunan, Peoples R China.
通讯机构:
[Sun, ZL; Liu, ZY] H
Hunan Agr Univ, Changsha 410128, Hunan, Peoples R China.
语种:
英文
关键词:
11 hydroxygelsenicine;11 methoxy 19 hydroxygelsegine;14 dehydrxoygelsefuranidine;14 hydroxygelsenicine;15 hydroxyhumantenine;19 akuammidine;19 hydroxdihyogelsemine;19 hydroxydigelsevirine;3 hydroxykoumidine;6 hydroxyhumantenine;alkaloid derivative;gelesmine;gelselegine;gelsemicine;gelsemine oxide;Gelsemium elegans extract;gelsemoxonine;gelsevirine;gs 2(11 methoxy 14 hydroxygelsenicine);humantenine;humantenmine;humantenoxenine;isomerofdehydrxoygelsefuranidine;koumidine;koumine;na desmethoxyhumantenine;nb methylgelsedilam;plant extract;unclassified drug;alkaloid;herbaceous agent;Article;calibration;controlled study;drug clearance;Gelsemium;Gelsemium elegans;herbal medicine;in vivo study;liquid chromatography-mass spectrometry;mean residence time;measurement accuracy;measurement precision;multiple reaction monitoring;pig;plasma concentration-time curve;priority journal;quantitative analysis;time of flight mass spectrometry;time to maximum plasma concentration;volume of distribution;animal;chemistry;feasibility study;Gelsemium;high performance liquid chromatography;oral drug administration;procedures;tandem mass spectrometry;Administration, Oral;Alkaloids;Animals;Chromatography, High Pressure Liquid;Drugs, Chinese Herbal;Feasibility Studies;Gelsemium;Sus scrofa;Tandem Mass Spectrometry
期刊:
Journal of Pharmaceutical and Biomedical Analysis
ISSN:
0731-7085
年:
2019
卷:
176
页码:
112833
基金类别:
This work was supported by the National Natural Science Foundation of China (Grant No. 31972737 ), the Hunan Provincial Natural Science Foundation of China (Grant No. 2017JJ1017 ) and the Scientific Research Fund of Hunan Provincial Education Department (No. 15B114, 18A088 ).
机构署名:
本校为第一且通讯机构
院系归属:
动物医学院
摘要:
The multicomponent pharmacokinetic study of herbal medicine is a great challenge due to the low plasma concentrations, large range of concentration scales, lack of authentic standards and uncertain interactions of the components. The aim of this work was to explore the in vivo pharmacokinetics of herbal medicine independently of authentic standards using an integrated analytical strategy. First, ion pairs of multiple components were tuned and selected, and then major parameters were optimized for derivative multiple reaction monitoring (DeMRM) ...

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