A zebrafish NLRX1 isoform downregulates fish IFN responses by targeting the adaptor STING

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期刊论文

作者：

Zhao, Xiang;An, Li-Li;Gong, Xiu-Ying;Dan, Cheng;Qu, Zi-Ling;...

通讯作者：

Zhang, YB

作者机构：

[An, Li-Li; Guo, Wen-Hao; Sun, Hao-Yu; Zhang, Yi-Bing; Gui, Jian-Fang; Zhao, Xiang; Zhang, YB; Dan, Cheng; Qu, Zi-Ling; Gong, Xiu-Ying] Chinese Acad Sci, Inst Hydrobiol, Key Lab Breeding Biotechnol & Sustainable Aquacult, Wuhan, Peoples R China.

[Zhao, Xiang] Hunan Agr Univ, Fisheries Coll, Yue lu shan Lab, Changsha, Peoples R China.

[An, Li-Li; Guo, Wen-Hao; Sun, Hao-Yu; Zhang, Yi-Bing; Gui, Jian-Fang; Zhang, YB; Dan, Cheng; Qu, Zi-Ling; Gong, Xiu-Ying] Univ Chinese Acad Sci, Beijing, Peoples R China.

[Zhang, Yi-Bing; Gui, Jian-Fang; Zhang, YB] Chinese Acad Sci, Innovat Acad Seed Design, Wuhan, Peoples R China.

通讯机构：

[Zhang, YB ] C

Chinese Acad Sci, Inst Hydrobiol, Key Lab Breeding Biotechnol & Sustainable Aquacult, Wuhan, Peoples R China.

Univ Chinese Acad Sci, Beijing, Peoples R China.

Chinese Acad Sci, Innovat Acad Seed Design, Wuhan, Peoples R China.

语种：

英文

关键词：

IFN antiviral response;NLRX1;negative regulation;protein degradation;transcript variant 4

期刊：

Journal of Virology

ISSN：

0022-538X

年：

2024

卷：

期：

页码：

e0180123

DOI：

10.1128/jvi.01801-23

基金类别：

MOST | National Key Research and Development Program of China (NKPs)

机构署名：

本校为其他机构

摘要：

In mammals, NLRX1 is a unique member of the nucleotide-binding domain and leucine-rich repeat (NLR) family showing an ability to negatively regulate IFN antiviral immunity. Intron-containing genes, including NLRX1, have more than one transcript due to alternative splicing; however, little is known about the function of its splicing variants. Here, we identified a transcript variant of NLRX1 in zebrafish (Danio rerio), termed NLRX1-tv4, as a negative regulator of fish IFN response. Zebrafish NLRX1-tv4 was slightly induced by viral infection, with an expression pattern similar to the full-length...

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A zebrafish NLRX1 isoform downregulates fish IFN responses by targeting the adaptor STING

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