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Integrated Study on the Genome, Transcriptome, and Metabolome of Gelsemium elegans and Mining of Related Enzyme Genes Involved in Koumine Biosynthesis

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成果类型:
期刊论文
作者:
Yao Zhang;Li-Mei Pan;Yi-Song Liu;De-Tian Mu;Wen-Qiang Chen;...
通讯作者:
Zhao-Ying Liu
作者机构:
[Yao Zhang; De-Tian Mu; Wen-Qiang Chen; Ying Lu; Li-Ya Wang; Qi Tang] College of Horticulture, Yuelushan Laboratory & National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China
[Li-Mei Pan] Guangxi Key Laboratory of for High-Quality Formation and Utilization of Dao-Di Herbs, National Center for TCM Inheritance and Innovation, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China
[Yi-Song Liu; Meng-Ting Zuo; Zhao-Ying Liu] College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, Hunan, China
[Iain W. Wilson] CSIRO Agriculture and Food, Canberra, ACT 2601, Australia
[De-You Qiu] State Key Laboratory of Tree Genetics and Breeding, Research Institute of Forestry, Chinese Academy of Forestry, Beijing, 100091, China
通讯机构:
[Zhao-Ying Liu] C
College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, Hunan, China
语种:
英文
期刊:
Plant Physiology and Biochemistry
ISSN:
0981-9428
年:
2025
页码:
110069
机构署名:
本校为第一且通讯机构
院系归属:
园艺园林学院
动物医学院
摘要:
Gelsemium elegans a plant of the Loganiaceae family, is highly toxic and contains many alkaloids of potential pharmacological value. Koumine, is the most abundant component of G. elegans , and belongs to monoterpene indole alkaloids and is valued in medical research as it has important anti-inflammatory and anxiolytic properties. The biosynthesis pathway of this compound has been little studied, and is poorly understood, limiting the ability to improve koumine production via breeding or synthetic biology. To investigate G. elegans biosynthesis of koumine, its genomes was sequenced and assemble...

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