Integrated Study on the Genome, Transcriptome, and Metabolome of Gelsemium elegans and Mining of Related Enzyme Genes Involved in Koumine Biosynthesis

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成果类型：

期刊论文

作者：

Zhang, Yao;Pan, Li-Mei;Liu, Yi-Song;Mu, De-Tian;Chen, Wen-Qiang;...

通讯作者：

Tang, Q;Liu, ZY

作者机构：

[Tang, Qi; Lu, Ying; Chen, Wen-Qiang; Mu, De-Tian; Zhang, Yao; Wang, Li-Ya; Tang, Q] Hunan Agr Univ, Coll Hort, Yuelushan Lab, Changsha 410128, Peoples R China.

[Tang, Qi; Lu, Ying; Chen, Wen-Qiang; Mu, De-Tian; Zhang, Yao; Wang, Li-Ya; Tang, Q] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingre, Changsha 410128, Peoples R China.

[Pan, Li-Mei] Guangxi Bot Garden Med Plants, Key Lab High Qual Format & Utilizat Dao Di Herbs, Nanning 530023, Peoples R China.

[Liu, Zhao-Ying; Liu, Yi-Song; Zuo, Meng-Ting] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Wilson, Iain W.] CSIRO Agr & Food, Canberra, ACT 2601, Australia.

通讯机构：

[Tang, Q ; Liu, ZY ] H

Hunan Agr Univ, Coll Hort, Yuelushan Lab, Changsha 410128, Peoples R China.

Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingre, Changsha 410128, Peoples R China.

Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Biosynthesis;Co-expression;Gelsemium elegans;Koumine;PacBio;RNA-Seq

期刊：

Plant Physiology and Biochemistry

ISSN：

0981-9428

年：

2025

卷：

227

页码：

110069

DOI：

10.1016/j.plaphy.2025.110069

基金类别：

Scientific Research Project of Hunan Agriculture University [2024XKJC02]; Postgraduate Scientific Research Innovation Project of Hunan Province [CX20220689]; Postgraduate Scientific Research Innovation Project of Hunan Agricul-ture University [2022XC062]

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

动物医学院

摘要：

Gelsemium elegans a plant of the Loganiaceae family, is highly toxic and contains many alkaloids of potential pharmacological value. Koumine, is the most abundant component of G. elegans , and belongs to monoterpene indole alkaloids and is valued in medical research as it has important anti-inflammatory and anxiolytic properties. The biosynthesis pathway of this compound has been little studied, and is poorly understood, limiting the ability to improve koumine production via breeding or synthetic biology. To investigate G. elegans biosynthesis of koumine, its genomes was sequenced and assemble...

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Integrated Study on the Genome, Transcriptome, and Metabolome of Gelsemium elegans and Mining of Related Enzyme Genes Involved in Koumine Biosynthesis

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