Fuzhuan brick tea ameliorates hepatic steatosis and steatohepatitis through gut microbiota-derived aryl hydrocarbon receptor ligands in high-fat diet-induced obese mice

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成果类型：

期刊论文

作者：

Liu, Dongmin;Wang, Siyu;Liu, Yaqing;Luo, Yong;Wen, Beibei;...

通讯作者：

Liu, ZH

作者机构：

[Liu, Yaqing; Liu, Dongmin; Wang, Siyu] Changsha Univ Sci & Technol, Changsha 410114, Peoples R China.

[Wen, Beibei; Liu, Dongmin; Liu, Zhonghua; Luo, Yong; Wu, Wenliang; Huang, Jianan] Hunan Agr Univ, Key Lab Minist Educ Tea Sci, Changsha 410128, Peoples R China.

[Wen, Beibei; Liu, Zhonghua; Luo, Yong; Huang, Jianan] Natl Res Ctr Engn Technol Utilizat Bot Funct Ingre, Changsha 410128, Peoples R China.

[Wu, Wenliang] Hunan Acad Agr Sci, Tea Res Inst, Changsha 410125, Peoples R China.

[Zeng, Hongliang] Hunan Acad Chinese Med, Res Inst Chinese Med, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Liu, ZH ] H

Hunan Agr Univ, Key Lab Minist Educ Tea Sci, Changsha 410128, Peoples R China.

Natl Res Ctr Engn Technol Utilizat Bot Funct Ingre, Changsha 410128, Peoples R China.

语种：

英文

期刊：

FOOD & FUNCTION

ISSN：

2042-6496

年：

2023

卷：

期：

页码：

8351-8368

DOI：

10.1039/d3fo01782f

基金类别：

China Agriculture Research System of MOF and MARA [CARS-19-09B, CARS-23]; National Natural Science Foundation of China [31471706]; Scientific Research Fund of Hunan Provincial Education Department Provincial [21B0308]; Natural Science Foundation of Hunan [2020JJ5570]; Changsha University of Science amp; Technology; Key Laboratory of Ministry of Education for Tea Science in China; National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients in China

机构署名：

本校为通讯机构

院系归属：

园艺园林学院

摘要：

High-fat diet (HFD) induced obesity and its associated conditions, such as hepatic steatosis and steatohepatitis, are major health concerns worldwide. Previous studies have reported the excellent efficiency of Fuzhuan brick tea (FBT) in attenuating HFD-induced obesity and metabolic disorders. In this study, we investigated the effects of FBT on hepatic steatosis and simple steatohepatitis in HFD-induced obese mice, as well as the metabolic function of the gut microbiome using metagenomics and metabolomics. The results showed that FBT ameliorate...

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Fuzhuan brick tea ameliorates hepatic steatosis and steatohepatitis through gut microbiota-derived aryl hydrocarbon receptor ligands in high-fat diet-induced obese mice

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