期刊论文

Maoliang, Ran;Bin, Chen

英文

Genomics

0888-7543

2022

114

5

110450

10.1016/j.ygeno.2022.110450

This work was financially supported by key R&D projects in Hunan Province ( 2020NK2024 ), an earmarked fund for the Hunan Provincial Agriculture Research System, and the Hunan Provincial Natural Science Foundation of China ( 2020JJ4348 ). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

本校为第一机构

DNA methylation is one of the key epigenetic regulatory mechanisms in development and spermatogenesis. However, the dynamic regulatory mechanisms of genome-wide DNA methylation during testicular development remain largely unknown. Herein, we generated a single-base resolution DNA methylome and transcriptome atlas of precocious porcine testicular tissues across three developmental stages (1, 75, and 150 days old). The results showed that the dynamic methylation patterns were directly related to the expression of the DNMT3A gene. Conjoint analys...