In order to research the effects of Improvac immune control vaccine on coefficients of COD and NH3-N,a contrast experiment was conducted among Hainan province,Hunan province and Heilongjiang province.The results indicated that Improvac immune control vaccine has universality,and its effects were little impact by regional climate or the size of breeding.The coefficients of COD and NH3-N were different with different breeding methods.Compared with the traditional manual surgical castration model,Improvac immune control vaccine s...