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Evaluation of PCV2 vaccine immunogenicity and efficacy using ELISpot to detect virus-specific memory B cells

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成果类型:
期刊论文
作者:
Fan, Jie;Fan, Fangcheng;Chen, Zhixiong;Chen, Ping;Zhu, Yanli;...
通讯作者:
Ge, M
作者机构:
[Fan, Jie; Zhu, Yanli; Liu, Tiantian; Chen, Ping; Li, Runcheng; Ge, Meng; Fan, Fangcheng; Chen, Zhixiong; Li, Xin; Ge, M; Dong, Wei] Hunan Agr Univ, Coll Vet Med, Changsha 410125, Peoples R China.
通讯机构:
[Ge, M ] H
Hunan Agr Univ, Coll Vet Med, Changsha 410125, Peoples R China.
语种:
英文
关键词:
Porcine circovirus 2;ELISpot;Memory B cells;Immune memory;Vaccine
期刊:
Porcine Health Management
ISSN:
2055-5660
年:
2025
卷:
11
期:
1
页码:
1-10
基金类别:
The study was supported by the National Natural Science Foundation of China (Grant No. 32072871) and the Hunan Provincial Key Research and Development Program (2023NK2017).
机构署名:
本校为第一且通讯机构
院系归属:
动物医学院
摘要:
Porcine Circovirus 2 (PCV2) vaccination plays a crucial role in preventing porcine circovirus-associated disease (PCVAD). Nevertheless, pig farms face significant challenges in evaluating vaccination efficacy due to the inability of PCV2 vaccines to achieve sterilizing immunity and the variability among vaccine manufacturers. These challenges are further compounded by the limitations of conventional antibody detection methods, which fail to distinguish between maternally-derived antibodies (MDAs) and vaccine-induced antibodies. The accurate eva...

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