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Hepatitis B virus rigs the cellular metabolome to avoid innate immune recognition

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成果类型:
期刊论文
作者:
Jiang, Daohua;Tonggu, Lige;El-Din, Tamer M. Gamal;Banh, Richard;Pomes, Regis;...
通讯作者:
Liu, Shi
作者机构:
[Zheng, Ning; Tonggu, Lige; El-Din, Tamer M. Gamal; Jiang, Daohua; Catterall, William A.] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA.
[Banh, Richard; Pomes, Regis] Hosp Sick Children, Mol Med, Toronto, ON M5G 0A4, Canada.
[Banh, Richard; Pomes, Regis] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada.
[Zheng, Ning] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA.
通讯机构:
[Liu, Shi] S
State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
语种:
英文
期刊:
Nature Communications
ISSN:
2041-1723
年:
2021
卷:
12
期:
1
页码:
98
基金类别:
This work was supported by the Fundamental Research Funds for the Central Universities (2042020kf1015 to Fubing Wang, 2042017kf0221 to Shi Liu, 2042015kf0188 to Li Zhou), the National Natural Science Foundation of China (81872262 to Shi Liu, 31570870 to Ying Zhu, 81301428 to Li Zhou, 81972262 to Rui Zhang and 81802627 to Yi Yu), the Natural Science Foundation of Hubei Province (2017CFA022 to Shi Liu), Science and Technology Innovation Fostering Foundation of Zhongnan Hospital of Wuhan University (cxpy20160025 to Fubing Wang), and the Deutsche Forschungsgemeinschaft (TRR60 and RTG1949 to Mengji Lu and Mirko Trilling as well as TR 1208/1-1 and TR 1208/2-1 to Mirko Trilling).
机构署名:
本校为其他机构
院系归属:
生物科学技术学院
摘要:
Glucose metabolism and innate immunity evolved side-by-side. It is unclear if and how the two systems interact with each other during hepatitis B virus (HBV) infections and, if so, which mechanisms are involved. Here, we report that HBV activates glycolysis to impede retinoic acid-inducible gene I (RIG-I)-induced interferon production. We demonstrate that HBV sequesters MAVS from RIG-I by forming a ternary complex including hexokinase (HK). Using a series of pharmacological and genetic approaches, we provide in vitro and in vivo evidence indicating that HBV suppresses RLR signaling via lactate...

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