期刊论文

Progress on antiviral activity of interferon-induced transmembrane proteins

中文

微生物学免疫学进展

1005-5673

2019

47

6

81-86

10.13309/j.cnki.pmi.2019.06.015

国家自然科学基金（31372406）；

本校为第一机构

干扰素诱导跨膜蛋白(interferon-inducing transmembrane proteins,IFITM)是一类宿主限制性因子(host restric-tive factor,HRF),在抗病毒感染过程中发挥重要作用.IFITM作为一类氨基酸高度保守的抗病毒蛋白,在机体内广泛分布.随着对其研究的深入,发现该IFITM以多种通路/机制产生抗病毒感染的作用,使其作为研发抗病毒治疗药物的作用靶点成为可能.现就IFITM拓扑结构,抗病毒机制和抗病毒谱的研究作一概述.

Interferon-inducing transmembrane proteins(IFITM)are a class of host-restricting factors(HRF)that play an important role in antiviral activity.IFITM are widely distributed and highly conserved in vivo.As the research advances,IFITM have been identified to redtrict many virus by various pathaways or mechanisms,which make developing IFITM to potential antiviral medicines or vaccine targets possible.This paper describes the topology,ant...