期刊论文

Effects of duloxetine on depression behavior and SIOOB protein expression in hippocampus and prefrontal cortex in rats with early stress model

中文

中国慢性病预防与控制

1004-6194

2015

23

5

331-334

10.16386/j.cjpccd.issn.1004-6194.2015.05.029

国家自然科学基金资助项目（30900484） 天津市卫生局重点课题（2010KR10）

本校为第一机构

目的 研究度洛西汀对早期应激模型大鼠行为及海马和前额皮层星形胶质源性蛋白(S100B)的影响.方法 选取刚出生的54只清洁级雄性SD大鼠为实验动物,采用早期慢性应激制备36只抑郁模型大鼠,将其随机分为抑郁模型组和度洛西汀组,每组18只;对照组18只.度洛西汀组灌胃给予度洛西汀10 ml/kg,连续28 d,抑郁模型和对照组灌胃给予同体积蒸馏水,连续28 d.采用水迷宫试验、糖水偏爱试验检测大鼠的行为改变.采用免疫印迹法检测各组大鼠海马和前额皮层S100B的表达.结果 水迷宫试验结果显示,与抑郁模型组比较,度洛西汀组和对照组平均逃避潜伏期均明显缩短,差异有统计学意义(P＜0.05);对照组和度洛西汀组的平均逃...

Objective To study the effects of duloxetine on depression behavior and SIOOB protein expression in hippocampus and prefrontal cortex in rats with early stress model. Methods Fifty-four SD rats were randomly divided into early stress model group （ 18 rats）, early stress model with duloxetine group （ 18 rats） and control group （ 18 rats）, 10 ml/kg duloxetine was given to duloxetine group and distilled water was given to model and control groups by intragastric administration for 28 days. The Morris water maze test and the saccharine prefer...