期刊论文

Chen, Xuemei

英文

PLANT CELL

1040-4651

2014

26

7

2803-2817

10.1105/tpc.114.124941

National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [GM061146]; Howard Hughes Medical InstituteHoward Hughes Medical Institute; Gordon and Betty Moore FoundationGordon and Betty Moore Foundation [GBMF3046]; National Basic Research Program of ChinaNational Basic Research Program of China [2014CB138100]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [91317312]; ChemGen IGERT [DGE0504249]; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146, R01GM061146] Funding Source: NIH RePORTER

本校为其他机构

It has been perplexing that DNA topoisomerases, enzymes that release DNA supercoils, play specific roles in development. In this study, using a floral stem cell model in Arabidopsis thaliana, we uncovered a role for TOPOISOMERASE1α (TOP1α) in Polycomb Group (PcG) protein-mediated histone 3 lysine 27 trimethylation (H3K27me3) at, and transcriptional repression of, the stem cell maintenance gene WUSCHEL (WUS). We demonstrated that H3K27me3 deposition at other PcG targets also requires TOP1α. Intriguingly, the repression of some, as well as the...