Single-base editing in IGF2 improves meat production and intramuscular fat deposition in Liang Guang Small Spotted pigs

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成果类型：

期刊论文

作者：

Duo, Tianqi;Liu, Xiaohong;Mo, Delin;Bian, Yu;Cai, Shufang;...

通讯作者：

Chen, Yaosheng;He, ZY

作者机构：

[Liang, Ziyun; Chen, Shiyi; He, Zuyong; Chen, Yaosheng; Mo, Delin; Li, Ruiqiang; Tong, Xian; Chen, YS; Duo, Tianqi; Jiang, Weilun; Liu, Xiaohong; Wang, Min; Zhu, Qi; Cai, Shufang] Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China.

[Bian, Yu] Harbin Med Univ, Coll Pharm, Dept Pharmacol, State Prov Key Labs Biomed Pharmaceut China, Harbin 150081, Peoples R China.

[Cai, Shufang] Hunan Agr Univ, Coll Anim Sci & Technol, Hunan Prov Key Lab Genet Improvement Domest Anim, Changsha 410128, Peoples R China.

通讯机构：

[He, ZY ; Chen, YS] S

Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China.

语种：

英文

关键词：

CBE3;IGF2;Intramuscular fat;Meat production;PI3K-AKT/AMPK;ZBED6

期刊：

畜牧与生物技术杂志(英文版)

ISSN：

1674-9782

年：

2023

卷：

期：

页码：

1-19

DOI：

10.1186/s40104-023-00930-4

基金类别：

This research was supported by the National Natural Science Foundation of China (32072697; 32030102); CARS-PIG-35; R&D Programmes of Guangdong Province (2018B020203003); Laboratory of Lingnan Modern Agriculture Project (NZ2021006).

机构署名：

本校为其他机构

院系归属：

动物科学技术学院

摘要：

Chinese indigenous pigs are popular with consumers for their juiciness, flavour and meat quality, but they have lower meat production. Insulin-like growth factor 2 (IGF2) is a maternally imprinted growth factor that promotes skeletal muscle growth by regulating cell proliferation and differentiation. A single nucleotide polymorphism (SNP) within intron 3 of porcine IGF2 disrupts a binding site for the repressor, zinc finger BED-type containing 6 (ZBED6), leading to up-regulation of IGF2 and causing major effects on muscle growth, heart size, an...

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Single-base editing in IGF2 improves meat production and intramuscular fat deposition in Liang Guang Small Spotted pigs

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