Flavonoids and type 2 diabetes: Evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hussain, Tarique;Tan, Bie*;Murtaza, Ghulam;Liu, Gang;Rahu, Najma;...

通讯作者：

Tan, Bie

作者机构：

[Liu, Gang; Tan, Bie; Yin, Yulong; Hussain, Tarique] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.

[Liu, Gang; Adebowale, Tolulope O.; Tan, Bie; Yin, Yulong; Hussain, Tarique] Chinese Acad Sci, Natl Engn Lab Pollut Control & Waste Utilizat Liv, Key Lab Agroecol Proc Subtrop Reg, Inst Subtrop Agr,Lab Anim Nutr Physiol & Metab Pr, Changsha 410125, Hunan, Peoples R China.

[Mazhar, Muhammad Usman; Hussain, Tarique] NIAB, Anim Sci Div, POB 128,Jhang Rd, Faisalabad 38000, Pakistan.

[Murtaza, Ghulam] Shaheed Benazir Bhutto Univ Vet & Anim Sci, Sakrand 67210, Sindh, Pakistan.

[Rahu, Najma; Kalhoro, Dildar Hussain] Sindh Agr Univ, Fac Anim Husb & Vet Sci, Dept Vet Microbiol, Tandojam 70050, Sindh, Pakistan.

通讯机构：

[Tan, Bie] H

Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Inflammation and flavonoids;Oxidative stress;T2DM

期刊：

Pharmacological Research

ISSN：

1043-6618

年：

2020

卷：

152

页码：

104629

DOI：

10.1016/j.phrs.2020.104629

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31960666, 31872991]; Earmarked Fund for China Agriculture Research System [CARS-35]; Open Fund of National and Local United Engineering Laboratory of Integrative Utilization Technology of Eucommia ulmoides [NLE201703]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学技术学院

摘要：

Diabetes mellitus type 2 (T2DM) is a metabolic disorder develops due to the overproduction of free radicals where oxidative stress could contribute it. Possible factors are defective insulin signals, glucose oxidation, and degradation of glycated proteins as well as alteration in glutathione metabolism which induced hyperglycemia. Previous studies revealed a link between T2DM with oxidative stress, inflammation and insulin resistance which are assumed to be regulated by numerous cellular networks such as NF-κB, PI3K/Akt, MAPK, GSK3 and PPARγ....

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Flavonoids and type 2 diabetes: Evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy

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