Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats

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成果类型：

期刊论文

作者：

Zhou, Xuqing;Wang, Xu;Li, Jiaqi;Zhang, Mengxue;Yang, Yi;...

通讯作者：

Guo, C

作者机构：

[Zhou, Xuqing; Guo, C; Wang, Xu; Guo, Chun; Lei, Shihui; Yang, Yi] Hunan Univ Chinese Med, Hosp 1, Expt Ctr Med Innovat, Changsha 410007, Hunan, Peoples R China.

[Zhou, Xuqing; Guo, C; Wang, Xu; Guo, Chun] Hunan Univ Chinese Med, Clin Coll Tradit Chinese Med 1, Changsha 410007, Hunan, Peoples R China.

[Li, Jiaqi; He, Ying; Yang, Hua] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

[Zhang, Mengxue; Zhou, Desheng] Hunan Univ Chinese Med, Hosp 1, Dept Neurol, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Guo, C ] H

Hunan Univ Chinese Med, Hosp 1, Expt Ctr Med Innovat, Changsha 410007, Hunan, Peoples R China.

Hunan Univ Chinese Med, Clin Coll Tradit Chinese Med 1, Changsha 410007, Hunan, Peoples R China.

语种：

英文

关键词：

Annao Pingchong decoction;SIRT1;intracerebral hemorrhage;network pharmacology;oxidative stress;vivo experiments

期刊：

Drug Design, Development and Therapy

ISSN：

1177-8881

年：

2024

卷：

页码：

699-717

DOI：

10.2147/DDDT.S439873

基金类别：

National Natural Science Foundation of China [81874463]; Natural Science Foundation of Hunan Province [2019JJ50466]; Research Foundation of Health Commission of Hunan Province [20233472]; Natural Science Foundation of Changsha [Kq2208208]; Department of Agriculture and Rural Affairs of Hunan Province Research Project [2130111]

机构署名：

本校为其他机构

院系归属：

生物科学技术学院

摘要：

BACKGROUND: Annao Pingchong decoction (ANPCD) is a traditional Chinese decoction which has definite effects on treating intracerebral hemorrhage (ICH) validated through clinical and experimental studies. However, the impact of ANPCD on oxidative stress (OS) after ICH remains unclear and is worth further investigating. AIM: To investigate whether the therapeutic effects of ANPCD on ICH are related to alleviating OS damage and seek potential targets for its antioxidant effects. MATERIALS AND METHODS: The therapeutic candidate genes of ANPCD on IC...

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Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats

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