期刊论文

Wenbing Zhang

英文

Cells

2073-4409

2023

12

7

1098-

10.3390/cells12071098

M.Y. performed the experiments and wrote the manuscript. M.P. and D.H. performed the experiments. J.L., Y.G. and Y.L. revised the manuscript. W.Z. acquired funding, designed the experiments, and revised the manuscript. All authors have read and agreed to the published version of the manuscript. This work was financially supported by the National Key R & D Program of China, grant number 2019YFD0900200.

本校为其他机构

In order to investigate the mechanism of glucagon regulation of gluconeogenesis, primary hepatocytes of the Japanese flounder (Paralichthys olivaceus) were incubated with synthesized glucagon, and methods based on inhibitors and gene overexpression were employed. The results indicated that glucagon promoted glucose production and increased the mRNA levels of glucagon receptor (gcgr), guanine nucleotide-binding protein Gs α subunit (gnas), adenylate cyclase 2 (adcy2), protein kinase A (pka), cAMP response element-binding protein 1 (creb1), pero...