Adriamycin is an antitumor agent and its amphipathic characteristic makes interaction at the level of the cellular surface possible. In this paper, we studied the insertion behaviour of adriamycin and its metallic derivative, triferric adriamycin i.e., quelamycin, into lipid membrane with vesicles and supported bilayer lipid membrane as model membranes formed by neutral lipids. Observed from UV-VIS absorption spectroscopy, quelamycin could interact with vesicles in athiamycin-iron complex form. In the fluorescence measurements, adriamycin and triferric adriamycin could insert into the bilayer ...
