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Melatonin shapes bacterial clearance function of porcine macrophages during enterotoxigenic Escherichia coli infection

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成果类型:
期刊论文
作者:
Du, Lingfei;Liu, Bingnan;Han, Ziyi;Xia, Yaoyao;Wu, Miaomiao;...
通讯作者:
Shaojuan Liu
作者机构:
[Du, Lingfei; Xia, Yaoyao; Liu, Shaojuan; Liu, Bingnan; Han, Ziyi] South China Agr Univ, Coll Anim Sci, Guangdong Lab Lingnan Modern Agr, Guangzhou, Peoples R China.
[Wu, Miaomiao] Hunan Agr Univ, Coll Anim Sci & Technol, Anim Nutr Genome & Germplasm Innovat Res Ctr, Changsha, Peoples R China.
通讯机构:
[Shaojuan Liu] G
Guangdong Laboratory of Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, China
语种:
英文
关键词:
Porcine macrophage;Melatonin;Enterotoxigenic Escherichia coli;Serotonin pathway
期刊:
动物营养(英文)
ISSN:
2405-6545
年:
2022
卷:
11
期:
4
页码:
242-251
基金类别:
The authors would like to thank Prof. Huahua Du for providing 3D4/21 cells and Prof. Guoqiang Zhu for providing the strains used in the experiment. This work was jointly supported by the National Key R&D Program of China (2021YFD1301100) and Laboratory of Lingnan Modern Agriculture Project (NT2021005).
机构署名:
本校为其他机构
院系归属:
动物科学技术学院
摘要:
Due to the immature gastrointestinal immune system, weaning piglets are highly susceptible to path-ogens, e.g., enterotoxigenic Escherichia coli (ETEC). Generally, pathogens activate the immune cells (e.g., macrophages) and shape intracellular metabolism (including amino acid metabolism); nevertheless, the metabolic cues of tryptophan (especially melatonin pathway) in directing porcine macrophage function during ETEC infection remain unclear. Therefore, this study aimed to investigate the changes in the serotonin pathway of porcine macrophages during ETEC infection and the effect of melatonin ...
摘要(中文):
Due to the immature gastrointestinal immune system,weaning piglets are highly susceptible to pathogens,e.g.,en...展开更多 Due to the immature gastrointestinal immune system,weaning piglets are highly susceptible to pathogens,e.g.,enterotoxigenic Escherichia coli(ETEC).Generally,pathogens activate the immune cells(e.g.,macrophages)and shape intracellular metabolism(including amino acid metabolism);nevertheless,the metabolic cues of tryptophan(especially melatonin pathway)in directing porcine macrophage function during ETEC infection remain uncle...

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