Sirtuin 3 inhibits nuclear factor-κB signaling activated by a fatty acid challenge in bovine mammary epithelial cells

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成果类型：

期刊论文

作者：

Liu, Lei;Lu, Hong;Loor, Juan J.;Aboragah, Ahmad;Du, Xiliang;...

通讯作者：

Li, Xinwei

作者机构：

[Lu, Hong; Peng, Tao; Liu, Lei; He, Jianhua; Su, Jianming] Hunan Agr Univ, Hunan Collaborat Innovat Ctr Safety Prod Livestoc, Coll Vet Med, Hunan Prov Key Lab Prot Engn Anim Vaccines, Changsha 410128, Peoples R China.

[Loor, Juan J.; Aboragah, Ahmad] Univ Illinois, Mammalian NutriPhysioGen, Dept Anim Sci, Urbana, IL 61801 USA.

[Loor, Juan J.; Aboragah, Ahmad] Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA.

[Wang, Zhe; Liu, Guowen; Du, Xiliang; Li, Xinwei] Jilin Univ, Key Lab Zoonosis, Minist Educ, Coll Vet Med, 5333 Xian Rd, Changchun 130062, Jilin, Peoples R China.

通讯机构：

[Li, Xinwei] J

Jilin Univ, Key Lab Zoonosis, Minist Educ, Coll Vet Med, 5333 Xian Rd, Changchun 130062, Jilin, Peoples R China.

语种：

英文

关键词：

ketosis;mastitis;nonesterified fatty acid;bovine mammary epithelial cell

期刊：

Journal of Dairy Science

ISSN：

0022-0302

年：

2021

卷：

104

期：

页码：

12871-12880

DOI：

10.3168/jds.2021-20536

基金类别：

China Postdoctoral Science Foundation (Beijing, China) [2017M612561]; National Natural Science Foundation of China (Beijing, China)National Natural Science Foundation of China (NSFC) [31502135, 32022084]; Scientific Research Foundation for the introduction of talent in Hunan Agricultural University (Changsha, China) [15YJ05]; Science Fund for Distinguished Young Scholars of Changsha City, China [kq2009055]

机构署名：

本校为第一机构

院系归属：

动物医学院

摘要：

Susceptibility to mastitis is highest during the peri-partal (transition) period and is often concomitant with other comorbidities such as ketosis. Although infection with pathogenic microorganisms and immune-dysfunc-tion around calving clearly play key roles in mastitis development, other metabolic factors also contribute. Sirtuin 3 (SIRT3), a mitochondrial deacetylase regu-lating energy and redox homeostasis, antagonizes the lipotoxic effects of nonesterified fatty acids (NEFA). Thus, we hypothesized that increases in circulating NEFA concentrations, as observed in the transition period, pro...

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Sirtuin 3 inhibits nuclear factor-κB signaling activated by a fatty acid challenge in bovine mammary epithelial cells

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