Neuroprotective Effects of Theaflavins Against Oxidative Stress-Induced Apoptosis in PC12 Cells

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成果类型：

期刊论文

作者：

Zhang, Jing;Cai, Shuxian;Li, Juan;Xiong, Ligui;Tian, Lili;...

通讯作者：

Huang, Jianan;Liu, Zhonghua

作者机构：

[Zhang, Jing; Liu, Jianjun; Tian, Lili; Liu, Zhonghua; Xiong, Ligui; Huang, JN; Li, Juan; Huang, Jianan; Cai, Shuxian] Hunan Agr Univ, Minist Educ Tea Sci, Key Lab, Changsha 410128, Hunan, Peoples R China.

[Liu, Zhonghua; Huang, JN; Huang, Jianan] Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Changsha 410128, Hunan, Peoples R China.

[Liu, Zhonghua; Huang, JN; Huang, Jianan] Collaborat Innovat Ctr Utilizat Funct Ingredients, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Huang, JN; Liu, ZH] H

[Huang, JN; Liu, ZH] N

[Huang, JN; Liu, ZH] C

Hunan Agr Univ, Minist Educ Tea Sci, Key Lab, Changsha 410128, Hunan, Peoples R China.

Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Theaflavin;Neuroprotective effect;Oxidative stress;Apoptosis;PC12 cells

期刊：

Neurochemical Research

ISSN：

0364-3190

年：

2016

卷：

期：

页码：

3364-3372

DOI：

10.1007/s11064-016-2069-8

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31471590]; Hunan Collaborative Innovation Center of Utilization of Botanical Functional Ingredients Project, China [HNCR-2014003]; Key Project of National Technology System for Tea Industry in China [CARS-23-11B]

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

摘要：

Oxidative stress can induce neuronal apoptosis via the production of superoxide and hydroxyl radicals. This process is as a major pathogenic mechanism in neurodegenerative disorders. In this study, we aimed to clarify whether theaflavins protect PC12 cells from oxidative stress damage induced by H 2 O 2 . A cell model of PC12 cells undergoing oxidative stress was created by exposing cells to 200 μM H 2 O 2 in the presence or absence of varying concentrations of theaflavins (5, 10, and 20 μM). Cell viability was monitored using the MTT assay a...

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Neuroprotective Effects of Theaflavins Against Oxidative Stress-Induced Apoptosis in PC12 Cells

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