Effect of Dietary Exposure to Acrylamide on Diabetes-Associated Cognitive Dysfunction from the Perspectives of Oxidative Damage, Neuroinflammation, and Metabolic Disorders

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Quan, Wei;Li, Maiquan;Jiao, Ye;Zeng, Maomao;He, Zhiyong;...

通讯作者：

Quan, W

作者机构：

[Shen, Qingwu; Quan, Wei; Li, Maiquan; Quan, W] Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Hunan, Peoples R China.

[Jiao, Ye] Changsha Univ Sci & Technol, Sch Food Sci & Bioengn, Changsha 410114, Peoples R China.

[He, Zhiyong; Quan, Wei; Zeng, Maomao; Chen, Jie; Quan, W] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.

[Chen, Jie] Jiangnan Univ, Int Joint Lab Food Safety, Wuxi 214122, Jiangsu, Peoples R China.

通讯机构：

[Quan, W ] H

Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Hunan, Peoples R China.

Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.

语种：

英文

关键词：

acrylamide;oxidative damage;neuroinflammation;brain metabolomics;diabetes-associated cognitive dysfunction;glial cells

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2022

卷：

期：

页码：

4445-4456

DOI：

10.1021/acs.jafc.2c00662

基金类别：

National Natural Science Foundation of China [3217160166, 32001680]; Innovation and Exploration Fund of State Key Laboratory of Food Science and Technology, Jiangnan University [SKLF-ZZA-202001]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学技术学院

摘要：

Acrylamide is a toxic compound that is produced widely during food processing, but whether the daily dietary consumption of acrylamide can impair the cognitive dysfunction in diabetic individuals and the potential underlying mechanisms are unknown. The aim of the present study was to observe the changes in cognitive and memory performance caused by chronic acrylamide exposure and to evaluate its influence on the brain morphology, oxidative damage, neuroinflammation, and brain metabolic disturbance. Goto-Kakizaki (GK) rats, a rat model of diabet...

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Effect of Dietary Exposure to Acrylamide on Diabetes-Associated Cognitive Dysfunction from the Perspectives of Oxidative Damage, Neuroinflammation, and Metabolic Disorders

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